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Comparison of Tumor Size and Gene Expression at Presentation in Uveal Melanoma Patients before and during the COVID-19 Pandemic.
Hasegawa, Naomi; Rusakevich, Alexander; Bernicker, Eric; Teh, Bin S; Schefler, Amy.
  • Hasegawa N; aDepartment of Ophthalmology, University of Texas at Houston, Houston, Texas, USA.
  • Rusakevich A; bRetina Consultants of Texas, Houston, Texas, USA.
  • Bernicker E; cHouston Methodist Cancer Center, Houston Methodist Hospital, Houston, Texas, USA.
  • Teh BS; dDepartment of Radiation Oncology, Houston Methodist Hospital, Houston, Texas, USA.
  • Schefler A; bRetina Consultants of Texas, Houston, Texas, USA.
Ocul Oncol Pathol ; 8(3): 156-160, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2138274
ABSTRACT

Introduction:

The aim of this study was to compare the clinical and gene expression variables of uveal melanoma patients presenting before and after the start of the COVID-19 pandemic as surrogate markers in order to assess the pandemic's potential impact on care.

Methods:

We conducted a retrospective chart review of uveal melanoma patients at Retina Consultants of Texas and assessed tumor size, staging, and gene expression data during two time periods May 2019 to February 2020 (Group 1 Before the COVID-19 pandemic declaration by the WHO in March 2020) and May 2020 to March 2021 (Group 2 After the start of the COVID-19 pandemic).

Results:

A total of 80 patients with uveal melanoma were studied (Group 1 40 [50%] and Group 2 40 [50%]). There was no statistically significant difference in the tumor thickness (p = 0.768), largest base dimension (p = 0.758), Collaborative Ocular Melanoma Study size class (p = 0.762), and American Joint Committee on Cancer stages (p = 0.872) between the two groups. Additionally, there was no difference in the tumors' gene expression data including gene expression profile class (p = 0.587) and PRAME expressivity (p = 0.861) between the two groups. Discussion/

Conclusion:

The COVID-19 pandemic had no effect on the presentation of uveal melanoma patients across all tumor characteristics including size, staging, and gene expression data, suggesting there was not a significant diagnostic delay in care for uveal melanoma patients at our center due to the pandemic.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Ocul Oncol Pathol Year: 2022 Document Type: Article Affiliation country: 000524918

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Ocul Oncol Pathol Year: 2022 Document Type: Article Affiliation country: 000524918