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Neurological manifestations of COVID-19: a retrospective observational study based on 1060 patients with a narrative review.
Negro, Alberto; Tortora, Mario; Gemini, Laura; de Falco, Arturo; Somma, Francesco; d'Agostino, Vincenzo.
  • Negro A; Department of Neuroradiology, 508856Ospedale del Mare, Naples, Italy.
  • Tortora M; Department of Advanced Biomedical Sciences, 9307University "Federico II," Naples, Italy.
  • Gemini L; Department of Advanced Biomedical Sciences, 9307University "Federico II," Naples, Italy.
  • de Falco A; Department of Neurology, 508856Ospedale del Mare, Naples, Italy.
  • Somma F; Department of Neuroradiology, 508856Ospedale del Mare, Naples, Italy.
  • d'Agostino V; Department of Neuroradiology, 508856Ospedale del Mare, Naples, Italy.
Acta Radiol ; : 2841851221138557, 2022 Nov 30.
Article in English | MEDLINE | ID: covidwho-2317625
ABSTRACT

BACKGROUND:

In the past two decades, three coronavirus epidemics have been reported. Coronavirus disease 2019 (COVID-19) is caused by a severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). In most patients, the disease is characterized by interstitial pneumonia, but features can affect other organs.

PURPOSE:

To document the radiological features of the patients and to perform a narrative review of the literature. MATERIAL AND

METHODS:

We conducted a retrospective, single-center study on 1060 consecutive hospitalized patients with COVID-19 at our institution. According to the inclusion criteria, we selected patients to be studied in more radiological detail. All images were obtained as per standard of care protocols. We performed a statistic analysis to describe radiological features. We then presented a systematic review of the main and conventional neuroimaging findings in COVID-19.

RESULTS:

Of 1060 patients hospitalized for COVID-19 disease, 15% (159) met the eligibility criteria. Of these, 16 (10%) did not undergo radiological examinations for various reasons, while 143 (90%) were examined. Of these 143 patients, 48 (33.6%) had positive neuroimaging. We found that the most frequent pathology was acute ischemic stroke (n=16, 33.3%). Much less frequent were Guillain-Barre syndrome (n=9, 18.8%), cerebral venous thrombosis (n=7, 14.6%), encephalitis or myelitis (n=6, 12.5%), intracranial hemorrhage and posterior hemorrhagic encephalopathy syndrome (n=4, 8.3%), exacerbation of multiple sclerosis (n=4, 8.3%), and Miller-Fisher syndrome (n=2, 4.2%).

CONCLUSION:

Our data are coherent with the published literature. Knowledge of these patterns will make clinicians consider COVID-19 infection when unexplained neurological findings are encountered.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Acta Radiol Year: 2022 Document Type: Article Affiliation country: 02841851221138557

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Language: English Journal: Acta Radiol Year: 2022 Document Type: Article Affiliation country: 02841851221138557