Your browser doesn't support javascript.
Early Humoral Responses of Hemodialysis Patients After Inactivated SARS-CoV-2 Vaccination.
Zhao, Wen-Man; Shi, Rui; Wang, Peng; He, Jun; Chen, Yue; Feng, Ya-Ting; Pan, Hai-Feng; Wang, De-Guang.
  • Zhao WM; Department of Nephrology, The Second Hospital of Anhui Medical University, Hefei, People's Republic of China.
  • Shi R; Department of Nephrology, The Second Hospital of Anhui Medical University, Hefei, People's Republic of China.
  • Wang P; Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
  • He J; Anhui Provincial Center for Disease Control and Prevention, Hefei, People's Republic of China.
  • Chen Y; Public Health Research Institute of Anhui Province, Hefei, People's Republic of China.
  • Feng YT; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
  • Pan HF; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, People's Republic of China.
  • Wang DG; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
J Inflamm Res ; 15: 3467-3475, 2022.
Article in English | MEDLINE | ID: covidwho-2141144
ABSTRACT

Purpose:

To detect antibody responses to inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in patients undergoing hemodialysis and to investigate vaccine-related adverse events. Patients and

Methods:

A total of 120 hemodialysis (HD) patients and 24 healthy controls (HCs) who had not been previously infected with SARS-CoV-2 and had received their first dose of the inactivated vaccine (CoronaVac; Sinovac Biotech Ltd) were recruited for this study. All participants were scheduled to receive a second dose of inactivated SARS-CoV-2 vaccine. Serum-specific immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against the SARS-CoV-2 were detected at least 14 days after the second dose of vaccine using a commercial kit. Positive and negative results were defined as a sample/cutoff (S/CO) ratio≥1.00 and <1.00, respectively. Vaccination-related adverse events were assessed using a standardized questionnaire.

Results:

There were no significant differences regarding the seroprevalences of IgG and IgM antibodies against SARS-CoV-2 and the self-reported vaccination-related adverse events between HD patients and HCs. The analysis results for HD patients suggest that 82 (68.3%) and 27 (22.5%) tested positive for IgG and IgM, respectively. The levels of IgG were higher than IgM levels (P<0.0001). In addition, the IgG-positive group had significantly higher serum albumin levels than the IgG-negative group (P<0.05). Only mild vaccine-related adverse events were observed in two patients (1.66%) and in one healthy individual (4.2%).

Conclusion:

The seroprevalences of IgG and IgM antibodies against SARS-CoV-2 and vaccination-related adverse effects are similar between HD and HCs. The inactivated SARS-CoV-2 vaccine is effective and safe in inducing near-term immunity in hemodialysis patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Vaccines Language: English Journal: J Inflamm Res Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Vaccines Language: English Journal: J Inflamm Res Year: 2022 Document Type: Article