Case Report: A Severe Paediatric Presentation of COVID-19 in APDS2 Immunodeficiency.
Front Immunol
; 13: 881259, 2022.
Article
in English
| MEDLINE | ID: covidwho-2141875
ABSTRACT
Critical respiratory manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are rare in children, and little is known about how immunocompromised children respond to the infection. We report a case of a 4-year-old boy with activated PI3K delta syndrome type 2 (APDS2) with a protracted and severe COVID-19 course with both inflammatory and acute respiratory features. He was treated with remdesivir, nitazoxanide, high-dose corticosteroids, and tocilizumab and made a full recovery. We propose that remdesivir may be used in combination with nitazoxanide to improve viral clearance and reduce the chance of resistance in treating acute SARS-CoV-2 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Immunologic Deficiency Syndromes
Type of study:
Case report
/
Prognostic study
Limits:
Child
/
Child, preschool
/
Humans
/
Male
Language:
English
Journal:
Front Immunol
Year:
2022
Document Type:
Article
Affiliation country:
Fimmu.2022.881259
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