Your browser doesn't support javascript.
Roles and functions of SARS-CoV-2 proteins in host immune evasion.
Rashid, Farooq; Xie, Zhixun; Suleman, Muhammad; Shah, Abdullah; Khan, Suliman; Luo, Sisi.
  • Rashid F; Division of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.
  • Xie Z; Department of Biotechnology, Guangxi Veterinary Research Institute, Nanning, China.
  • Suleman M; Guangxi Key Laboratory of Veterinary Biotechnology, Nanning, China.
  • Shah A; Center for Biotechnology and Microbiology, University of Swat, Swat, Pakistan.
  • Khan S; Department of Biotechnology, Shaheed Benazir Bhutto University, Sheringal, Pakistan.
  • Luo S; Department of Medical Lab Technology, The University of Haripur, Haripur, Pakistan.
Front Immunol ; 13: 940756, 2022.
Article in English | MEDLINE | ID: covidwho-2141958
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes 16 non-structural proteins (NSPs), four structural proteins, and nine accessory proteins that play indispensable roles to suppress the production and signaling of type I and III interferons (IFNs). In this review, we discussed the functions and the underlying mechanisms of different proteins of SARS-CoV-2 that evade the host immune system by suppressing the IFN-ß production and TANK-binding kinase 1 (TBK1)/interferon regulatory factor 3 (IRF3)/signal transducer and activator of transcription (STAT)1 and STAT2 phosphorylation. We also described different viral proteins inhibiting the nuclear translocation of IRF3, nuclear factor-κB (NF-κB), and STATs. To date, the following proteins of SARS-CoV-2 including NSP1, NSP6, NSP8, NSP12, NSP13, NSP14, NSP15, open reading frame (ORF)3a, ORF6, ORF8, ORF9b, ORF10, and Membrane (M) protein have been well studied. However, the detailed mechanisms of immune evasion by NSP5, ORF3b, ORF9c, and Nucleocapsid (N) proteins are not well elucidated. Additionally, we also elaborated the perspectives of SARS-CoV-2 proteins.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.940756

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.940756