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Prevalence of SARS-CoV-2 infection and associated risk factors: A testing program and nested case-control study conducted at Sapienza University of Rome between March and June 2021.
Baccolini, Valentina; Siena, Leonardo Maria; Renzi, Erika; Migliara, Giuseppe; Colaprico, Corrado; Romano, Alessandra; Massimi, Azzurra; Marzuillo, Carolina; De Vito, Corrado; Casini, Leandro; Antonelli, Guido; Turriziani, Ombretta; Angeloni, Antonio; D'Alba, Fabrizio; Villari, Paolo; Polimeni, Antonella.
  • Baccolini V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Siena LM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Renzi E; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Migliara G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Colaprico C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Romano A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Massimi A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Marzuillo C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • De Vito C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Casini L; Special Office for Prevention, Protection and High Vigilance, Sapienza University of Rome, Rome, Italy.
  • Antonelli G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Turriziani O; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
  • Angeloni A; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
  • D'Alba F; Policlinico Umberto I Teaching Hospital, Rome, Italy.
  • Villari P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Polimeni A; Department of Oral and Maxillofacial Science, Sapienza University of Rome, Rome, Italy.
Front Public Health ; 10: 1010130, 2022.
Article in English | MEDLINE | ID: covidwho-2142344
ABSTRACT

Background:

To safely resume in-person activities during the COVID-19 pandemic, Sapienza University of Rome implemented rigorous infection prevention and control measures, a successful communication campaign and a free SARS-CoV-2 testing program. In this study, we describe the University's experience in carrying out such a program in the context of the COVID-19 response and identify risk factors for infection.

Methods:

Having identified resources, space, supplies and staff, from March to June 2021 Sapienza offered to all its enrollees a molecular test service (8.30 AM to 4 PM, Monday to Thursday). A test-negative case-control study was conducted within the program. Participants underwent structured interviews that investigated activity-related exposures in the 2 weeks before testing. Multivariable conditional logistic regression analyses were performed. Adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were calculated.

Results:

A total of 8,959 tests were administered, of which 56 were positive. The detection trend followed regional tendencies. Among 40 cases and 80 controls, multivariable analysis showed that a known exposure to a COVID-19 case increased the likelihood of infection (aOR 8.39, 95% CI 2.38-29.54), while having a job decreased it (aOR 0.23, 95% CI 0.06-0.88). Of factors that almost reached statistical significance, participation in activities in the university tended to reduce the risk (aOR 0.32, 95% CI 0.09-1.06), while attendance at private gatherings showed an increasing risk trend (aOR 3.48, 95% CI 0.95-12.79). Age, gender, activities in the community, visiting bars or restaurants, and use of public transportation were not relevant risk factors. When those students regularly attending the university campus were excluded from the analysis, the results were comparable, except that attending activities in the community came close to having a statistically significant effect (aOR 8.13, 95% CI 0.91-72.84).

Conclusions:

The testing program helped create a safe university environment. Furthermore, promoting preventive behavior and implementing rigorous measures in public places, as was the case in the university setting, contributed to limit the virus transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Qualitative research Limits: Humans Language: English Journal: Front Public Health Year: 2022 Document Type: Article Affiliation country: Fpubh.2022.1010130

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Qualitative research Limits: Humans Language: English Journal: Front Public Health Year: 2022 Document Type: Article Affiliation country: Fpubh.2022.1010130