Clinical Characterization of the Three Waves of COVID-19 Occurring in Southern Italy: Results of a Multicenter Cohort Study.
Int J Environ Res Public Health
; 19(23)2022 Nov 30.
Article
in English
| MEDLINE | ID: covidwho-2143153
ABSTRACT
AIMS:
To characterize patients hospitalized for COVID-19 in the three waves in Southern Italy.METHODS:
We conducted a multicenter observational cohort study involving seventeen COVID-19 Units in Campania, southern Italy All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection from 28 February 2020 to 31 May 2021, were enrolled.RESULTS:
Two thousand and fifteen COVID-19 hospitalized patients were enrolled; 392 (19%) in the first wave, 917 (45%) in the second and 706 (35%) in the third wave. Patients showed a less severe clinical outcome in the first wave than in the second and third waves (73%, 65% and 72%, respectively; p = 0.003), but hospitalization expressed in days was longer in the first wave [Median (Q1-Q3) 17 (13-25) v.s. 14 (9-21) and 14 (9-19), respectively, p = 0.001)] and also mortality during hospitalization was higher in the first wave than in the second and third waves 16.6% v.s. 11.3% and 6.5%, respectively (p = 0.0001). Multivariate analysis showed that older age [OR 1.069, CI (1046-1092); p = 0.001], a worse Charlson comorbidity index [OR 1042, CI (1233-1594; p = 0.0001] and enrolment during the first-wave [OR 1.917, CI (1.054-3.485; p = 0.033] were predictors of mortality in hospitalized patients.CONCLUSIONS:
Improved organization of the healthcare facilities and the increase in knowledge of clinical and therapeutic management have contributed to a trend in the reduction in mortality during the three waves of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Humans
Country/Region as subject:
Europa
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijerph192316003
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