Your browser doesn't support javascript.
Clinical Characterization of the Three Waves of COVID-19 Occurring in Southern Italy: Results of a Multicenter Cohort Study.
Pisaturo, Mariantonietta; Russo, Antonio; Pattapola, Viraj; Astorri, Roberta; Maggi, Paolo; Numis, Fabio Giuliano; Gentile, Ivan; Sangiovanni, Vincenzo; Rossomando, Annamaria; Gentile, Valeria; Calabria, Giosuele; Pisapia, Raffaella; Codella, Alessio Vinicio; Masullo, Alfonso; Iodice, Valentina; Giolitto, Giancarlo; Parrella, Roberto; Dell'Aquila, Giuseppina; Gambardella, Michele; Di Perna, Felicia; Coppola, Nicola.
  • Pisaturo M; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", 80138 Napoli, Italy.
  • Russo A; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", 80138 Napoli, Italy.
  • Pattapola V; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", 80138 Napoli, Italy.
  • Astorri R; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", 80138 Napoli, Italy.
  • Maggi P; Infectious Diseases Unit, A.O. S Anna e S Sebastiano Caserta, 81100 Caserta, Italy.
  • Numis FG; Emergency Unit, PO Santa Maria delle Grazie, 80078 Pozzuoli, Italy.
  • Gentile I; Infectious Disease Unit, University Federico II, 80138 Naples, Italy.
  • Sangiovanni V; Third Infectious Diseases Unit, AORN dei Colli, PO Cotugno, 80131 Naples, Italy.
  • Rossomando A; IV Infectious Disease Unit, AORN dei Coli, PO Cotugno, 80131 Naples, Italy.
  • Gentile V; Hepatic Infectious Disease Unit, AORN dei Colli, PO Cotugno, 80131 Naples, Italy.
  • Calabria G; IX Infectious Disease Unit, AORN dei Coli, PO Cotugno, 80131 Naples, Italy.
  • Pisapia R; First Infectious Disease Unit, AORN dei Coli, PO Cotugno, 80131 Naples, Italy.
  • Codella AV; Infectious Diseease Unit, A.O. San Pio, PO Rummo, 82010 Benevento, Italy.
  • Masullo A; Infectious Disease Unit, A.O. San Giovanni di Dio e Ruggi D'Aragona, 84135 Salerno, Italy.
  • Iodice V; VIII Infectious Disease Unit, AORN dei Coli, PO Cotugno, 80131 Naples, Italy.
  • Giolitto G; Infectious Disease Unit, Ospedale Maria S.S. Addolorata di Eboli, ASL Salerno, 84025 Eboli, Italy.
  • Parrella R; Respiratory Infectious Diseases Unit, AORN dei Colli, PO Cotugno, 80131 Naples, Italy.
  • Dell'Aquila G; Infectious Diseases Unit, AO Avellino, 83100 Avellino, Italy.
  • Gambardella M; Infectious Diseease Unit, PO S. Luca, Vallo della Lucania, ASL Salerno, 84078 Vallo della Lucania, Italy.
  • Di Perna F; Pneumology Unit, AORN Caserta, 81100 Caserta, Italy.
  • Coppola N; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", 80138 Napoli, Italy.
Int J Environ Res Public Health ; 19(23)2022 Nov 30.
Article in English | MEDLINE | ID: covidwho-2143153
ABSTRACT

AIMS:

To characterize patients hospitalized for COVID-19 in the three waves in Southern Italy.

METHODS:

We conducted a multicenter observational cohort study involving seventeen COVID-19 Units in Campania, southern Italy All adult (≥18 years) patients, hospitalized with a diagnosis of SARS-CoV-2 infection from 28 February 2020 to 31 May 2021, were enrolled.

RESULTS:

Two thousand and fifteen COVID-19 hospitalized patients were enrolled; 392 (19%) in the first wave, 917 (45%) in the second and 706 (35%) in the third wave. Patients showed a less severe clinical outcome in the first wave than in the second and third waves (73%, 65% and 72%, respectively; p = 0.003), but hospitalization expressed in days was longer in the first wave [Median (Q1-Q3) 17 (13-25) v.s. 14 (9-21) and 14 (9-19), respectively, p = 0.001)] and also mortality during hospitalization was higher in the first wave than in the second and third waves 16.6% v.s. 11.3% and 6.5%, respectively (p = 0.0001). Multivariate analysis showed that older age [OR 1.069, CI (1046-1092); p = 0.001], a worse Charlson comorbidity index [OR 1042, CI (1233-1594; p = 0.0001] and enrolment during the first-wave [OR 1.917, CI (1.054-3.485; p = 0.033] were predictors of mortality in hospitalized patients.

CONCLUSIONS:

Improved organization of the healthcare facilities and the increase in knowledge of clinical and therapeutic management have contributed to a trend in the reduction in mortality during the three waves of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Humans Country/Region as subject: Europa Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph192316003

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Humans Country/Region as subject: Europa Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph192316003