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Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications.
Arzumanian, Viktoriia A; Dolgalev, Georgii V; Kurbatov, Ilya Y; Kiseleva, Olga I; Poverennaya, Ekaterina V.
  • Arzumanian VA; Institute of Biomedical Chemistry, 119121 Moscow, Russia.
  • Dolgalev GV; Institute of Biomedical Chemistry, 119121 Moscow, Russia.
  • Kurbatov IY; Institute of Biomedical Chemistry, 119121 Moscow, Russia.
  • Kiseleva OI; Institute of Biomedical Chemistry, 119121 Moscow, Russia.
  • Poverennaya EV; Institute of Biomedical Chemistry, 119121 Moscow, Russia.
Int J Mol Sci ; 23(22)2022 Nov 10.
Article in English | MEDLINE | ID: covidwho-2143218
ABSTRACT
The alphabet of building blocks for RNA molecules is much larger than the standard four nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of these nucleotides into distinct chemical entities that are structurally and functionally different from their unmodified counterparts. Some of these modifications are constituent and critical for RNA functions, while others serve as dynamic markings to regulate the fate of specific RNA molecules. Together, these modifications form the epitranscriptome, an essential layer of cellular biochemistry. As of the time of writing this review, more than 300 distinct RNA modifications from all three life domains have been identified. However, only a few of the most well-established modifications are included in most reviews on this topic. To provide a complete overview of the current state of research on the epitranscriptome, we analyzed the extent of the available information for all known RNA modifications. We selected 25 modifications to describe in detail. Summarizing our findings, we describe the current status of research on most RNA modifications and identify further developments in this field.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA / RNA Processing, Post-Transcriptional Language: English Year: 2022 Document Type: Article Affiliation country: Ijms232213851

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA / RNA Processing, Post-Transcriptional Language: English Year: 2022 Document Type: Article Affiliation country: Ijms232213851