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Age-Related Mortality in STEMI Patients: Insight from One Year of HUB Centre Experience during the Pandemic.
Tumminello, Gabriele; D'Errico, Andrea; Maruccio, Alessio; Gentile, Domitilla; Barbieri, Lucia; Carugo, Stefano.
  • Tumminello G; Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy.
  • D'Errico A; Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy.
  • Maruccio A; Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy.
  • Gentile D; Cardiovascular Research Team, San Carlo Clinic, Via Bertola, 3, 20026 Novate Milanese, Italy.
  • Barbieri L; Department of Cardio-Toracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milano, Italy.
  • Carugo S; Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
J Cardiovasc Dev Dis ; 9(12)2022 Dec 02.
Article in English | MEDLINE | ID: covidwho-2143250
ABSTRACT

Background:

Old patients have a poor prognosis when affected by ST elevation myocardial infarction (STEMI). The aim of our study was to evaluate the impact of age on acute and mid-term mortality in STEMI patients over one year in the pandemic period.

Methods:

we collected data on 283 STEMI patients divided into three groups according to age (not old, "Not-O", ≤74 y/o; old, "O", 75−84 y/o; very old, "Very-O", ≥85 y/o).

Results:

the three groups did not differ in their clinical or procedural characteristics. The Very-O patients had a significantly increased incidence of in-hospital MACE (35%), mortality (30.0%), and percentage of cardiac death (25.0%). The only two independent predictors of in-hospital mortality were the ejection fraction (EF) [OR0.902 (95% CI) 0.868−0.938; p < 0.0001] and COVID-19 infection [OR3.177 (95% CI) 1.212−8.331; p = 0.019]. At follow-up (430 +/− days), the survival rates were decreased significatively among the age groups (Not-O 2.9% vs. O 14.8% vs. Very-O 28.6%; p < 0.0001), and the only two independent predictors of the follow-up mortality were the EF [OR0.935 (95% CI) 0.891−0.982; p = 0.007] and age [OR1.06 (95% CI) 1.018−1.110; p = 0.019].

Conclusions:

in very old patients, all the accessory procedures that may be performed should be accurately and independently weighed up in terms of the risk−benefit balance and the real impact on the quality of life because of the poor mid-term prognosis.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcdd9120432

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Jcdd9120432