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Update on Omega-3 Polyunsaturated Fatty Acids on Cardiovascular Health.
Rodriguez, Daniel; Lavie, Carl J; Elagizi, Andrew; Milani, Richard V.
  • Rodriguez D; John Ochsner Heart and Vascular Institute, Department of Cardiovascular Diseases, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA 70121, USA.
  • Lavie CJ; John Ochsner Heart and Vascular Institute, Department of Cardiovascular Diseases, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA 70121, USA.
  • Elagizi A; John Ochsner Heart and Vascular Institute, Department of Cardiovascular Diseases, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA 70121, USA.
  • Milani RV; John Ochsner Heart and Vascular Institute, Department of Cardiovascular Diseases, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, LA 70121, USA.
Nutrients ; 14(23)2022 Dec 03.
Article in English | MEDLINE | ID: covidwho-2143421
ABSTRACT
Twenty percent of deaths in the United States are secondary to cardiovascular diseases (CVD). In patients with hyperlipidemia and hypertriglyceridemia, studies have shown high atherosclerotic CVD (ASCVD) event rates despite the use of statins. Given the association of high triglyceride (TG) levels with elevated cholesterol and low levels of high-density lipoprotein cholesterol, the American Heart Association (AHA)/American College of Cardiology (ACC) cholesterol guidelines recommend using elevated TGs as a "risk-enhancing factor" for ASCVD and using omega 3 fatty acids (Ω3FAs) for patients with persistently elevated severe hypertriglyceridemia. Ω3FA, or fish oils (FOs), have been shown to reduce very high TG levels, hospitalizations, and CVD mortality in randomized controlled trials (RCTs). We have published the largest meta-analysis to date demonstrating significant effects on several CVD outcomes, especially fatal myocardial infarctions (MIs) and total MIs. Despite the most intensive research on Ω3FAs on CVD, their benefits have been demonstrated to cluster across multiple systems and pathologies, including autoimmune diseases, infectious diseases, chronic kidney disease, central nervous system diseases, and, most recently, the COVID-19 pandemic. A review and summary of the controversies surrounding Ω3FAs, some of the latest evidence-based findings, and the current and most updated recommendations on Ω3FAs are presented in this paper.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Hypertriglyceridemia / Fatty Acids, Omega-3 / Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 / Hyperlipidemias / Myocardial Infarction Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Country/Region as subject: North America Language: English Year: 2022 Document Type: Article Affiliation country: Nu14235146

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Hypertriglyceridemia / Fatty Acids, Omega-3 / Hydroxymethylglutaryl-CoA Reductase Inhibitors / COVID-19 / Hyperlipidemias / Myocardial Infarction Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Country/Region as subject: North America Language: English Year: 2022 Document Type: Article Affiliation country: Nu14235146