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Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African Populations.
Souris, Marc; Tshilolo, Léon; Parzy, Daniel; Lobaloba Ingoba, Line; Ntoumi, Francine; Kamgaing, Rachel; Ndour, Moussa; Mbongi, Destin; Phoba, Balthazar; Tshilolo, Marie-Anasthasie; Mbungu, René; Sosso, Martin Samuel; Fainguem, Nadine; Ndiaye Dieye, Tandakha; Sylla, Massamba; Morand, Pierre; Gonzalez, Jean-Paul.
  • Souris M; UMR Unité des Virus Émergents (UVE Aix-Marseille Univ-IRD 190-Inserm 1207), 13005 Marseille, France.
  • Tshilolo L; Centre Hospitalier Mère-Enfant Monkole, Kinshasa, Democratic Republic of the Congo.
  • Parzy D; Centre de Formation et d'Appui Sanitaire (CEFA), Mont-Ngafula, Kinshasa BP 817, Democratic Republic of the Congo.
  • Lobaloba Ingoba L; Defideva/Altadeva-Biological Lab (Inpack), Luminy Biotech, 13009 Marseille, France.
  • Ntoumi F; Fondation Congolaise pour la Recherche Médicale and Faculté des Sciences et Techniques, Brazaville, Democratic Republic of the Congo.
  • Kamgaing R; Fondation Congolaise pour la Recherche Médicale and Faculté des Sciences et Techniques, Brazaville, Democratic Republic of the Congo.
  • Ndour M; Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany.
  • Mbongi D; Centre International de Référence Chantal Biya (CIRCB), Yaoundé, Cameroon.
  • Phoba B; Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formation (IRESSEF), Plateforme d'Immunologie, Dakar 10200, Senegal.
  • Tshilolo MA; CHU Aristide le Dantec, Service d'Immunologie, Dakar 10200, Senegal.
  • Mbungu R; Centre de Formation et d'Appui Sanitaire (CEFA), Mont-Ngafula, Kinshasa BP 817, Democratic Republic of the Congo.
  • Sosso MS; Centre de Formation et d'Appui Sanitaire (CEFA), Mont-Ngafula, Kinshasa BP 817, Democratic Republic of the Congo.
  • Fainguem N; Centre de Formation et d'Appui Sanitaire (CEFA), Mont-Ngafula, Kinshasa BP 817, Democratic Republic of the Congo.
  • Ndiaye Dieye T; Centre de Formation et d'Appui Sanitaire (CEFA), Mont-Ngafula, Kinshasa BP 817, Democratic Republic of the Congo.
  • Sylla M; Centre International de Référence Chantal Biya (CIRCB), Yaoundé, Cameroon.
  • Morand P; Centre International de Référence Chantal Biya (CIRCB), Yaoundé, Cameroon.
  • Gonzalez JP; Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formation (IRESSEF), Plateforme d'Immunologie, Dakar 10200, Senegal.
Viruses ; 14(10)2022 10 14.
Article in English | MEDLINE | ID: covidwho-2143679
ABSTRACT
For more than two years after the emergence of COVID-19 (Coronavirus Disease-2019), significant regional differences in morbidity persist. These differences clearly show lower incidence rates in several regions of the African and Asian continents. The work reported here aimed to test the hypothesis of a pre-pandemic natural immunity acquired by some human populations in central and western Africa, which would, therefore, pose the hypothesis of an original antigenic sin with a virus antigenically close to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). To identify such pre-existing immunity, sera samples collected before the emergence of COVID-19 were tested to detect the presence of IgG reacting antibodies against SARS-CoV-2 proteins of major significance. Sera samples from French blood donors collected before the pandemic served as a control. The results showed a statistically significant difference of antibodies prevalence between the collected samples in Africa and the control samples collected in France. Given the novelty of our results, our next step consists in highlighting neutralizing antibodies to evaluate their potential for pre-pandemic protective acquired immunity against SARS-CoV-2. In conclusion, our results suggest that, in the investigated African sub-regions, the tested populations could have been potentially and partially pre-exposed, before the COVID-19 pandemic, to the antigens of a yet non-identified Coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14102259

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14102259