Your browser doesn't support javascript.
Structural Insight into the Resistance of the SARS-CoV-2 Omicron BA.4 and BA.5 Variants to Cilgavimab.
Fujita, Shigeru; Kosugi, Yusuke; Kimura, Izumi; Yamasoba, Daichi; Sato, Kei.
  • Fujita S; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.
  • Kosugi Y; Graduate School of Medicine, The University of Tokyo, Tokyo 1130033, Japan.
  • Kimura I; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.
  • Yamasoba D; Graduate School of Medicine, The University of Tokyo, Tokyo 1130033, Japan.
  • The Genotype To Phenotype Japan G P-Japan Consortium; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.
  • Sato K; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.
Viruses ; 14(12)2022 11 29.
Article in English | MEDLINE | ID: covidwho-2143720
ABSTRACT
We have recently revealed that the new SARS-CoV-2 Omicron sublineages BA.4 and BA.5 exhibit increased resistance to cilgavimab, a therapeutic monoclonal antibody, and the resistance to cilgavimab is attributed to the spike L452R substitution. However, it remains unclear how the spike L452R substitution renders resistance to cilgavimab. Here, we demonstrated that the increased resistance to cilgavimab of the spike L452R is possibly caused by the steric hindrance between cilgavimab and its binding interface on the spike. Our results suggest the importance of developing therapeutic antibodies that target SARS-CoV-2 variants harboring the spike L452R substitution.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Antibodies, Monoclonal Topics: Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14122677

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / Antibodies, Monoclonal Topics: Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14122677