Identification and Analysis the Polymorphism in FGA Gene among Covid-19 Patients in Babylon Province/Iraq

ABSTRACT

SARS-COV-2, a beta coronavirus, was discovered to be the virus that caused the coronavirus disease pandemic in 2019 (Covid-19). It's been proven that abnormal coagulation function has a role in COVID-19 illness progression. However, there is no apparent link between D-dimer levels and COVID-19 severity. The goal of the study was to see if there was a link between D-dimer levels and the severity of COVID-19 investigation of SNPs in FGA gene. Interactors have been found in a variety of proteins, and fibrinogen chains (FGA) are a type of fibrinogen, which is an anti-infective organ, the liver produces this glycoprotein. And serves as an important coagulation factor and an acute phase reactant;for its versatile role in coagulation, inflammation, blood viscosity, and the implications in the management of (COVID 19). Fibrinogen's role in acute COVID 19 patients and clot formation has been studied been investigated by researchers. There have been no research on the direct association of Fibrinogen alpha chain (FGA) with SARS-Cov-2 so far. The current study proved that FGA did not affect the vaccinated people, but effect of sars-cov2 infected patients. Sequencing study of the investigated section revealed 392 bp of the gene FGA. The presence of an insertion mutation in the fifth axon results in a shift in amino acid sequence from Histidine CAU (GTA) to Threonine ACA (TGT), resulting a change in the amino acid sequence. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.