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Simvastatin Therapy Increased miR-150-5pExpression in the Patients with Type 2 Diabetes and COVID-19.
AmeliMojarad, Mandana; AmeliMojarad, Melika; Pourmadian, Alireza.
  • AmeliMojarad M; Department of Biotechnology, Tehran University of Medical Science, Tehran, Iran, Mandanalee13@gmail.com.
  • AmeliMojarad M; Department of Biotechnology, Tehran University of Medical Science, Tehran, Iran.
  • Pourmadian A; Department of Biotechnology, Tehran University of Medical Science, Tehran, Iran.
Cell Physiol Biochem ; 56(6): 685-691, 2022 Nov 25.
Article in English | MEDLINE | ID: covidwho-2146449
ABSTRACT
BACKGROUND/

AIMS:

Corona virus disease 2019 (COVID-19) has become a deadly infectious disease, especially for those with co-morbidities such as diabetes. People with diabetes developing a viral infection, seem to have harder treatments due to fluctuations in blood glucose levels therefore, effective therapeutic approaches need to be considered for them. Statins are well-known lipid-lowering drugs; they also have anti-inflammatory and immunomodulatory effects and can impact on expression of microRNAs (miRNAs).

METHODS:

In this study we investigate the effects of simvastatin on the expression of miR-150-5p as a famous regulator of inflammation and its association with multiple cancers in 30 patients with Type 2 diabetes mellitus (T2DM) and COVID-19 compared to the COVID-19 hospitalized patients before and after treatment with simvastatin with real-time-PCR after 2month, and evaluate its targets gens and functions with the help of bioinformatics and GO enrichment analysis respectively.

RESULTS:

Our results showed that simvastatin can increase miR-150-5p and therefore down regulate expression of its target genes involving in immune stimulation and decrease lipid profile including LDL-C, total cholesterol, and ApoB, especially in the group with type 2 diabetes mellitus (T2DM) and COVID-19 compared to the patients with only COVID-19.

CONCLUSION:

Simvastatin as an anti-inflammatory agent can modulate miRNAs expression; it can be suggested as an adjunct therapy especially for T2DM patients with COVID-19. Further studies may help us for developing better treatments about therapeutic manipulation of miRNAs in vivo.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / Diabetes Mellitus, Type 2 / COVID-19 Drug Treatment Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Cell Physiol Biochem Journal subject: Biochemistry / Pharmacology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: MicroRNAs / Diabetes Mellitus, Type 2 / COVID-19 Drug Treatment Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Cell Physiol Biochem Journal subject: Biochemistry / Pharmacology Year: 2022 Document Type: Article