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Age-related seroprevalence trajectories of seasonal coronaviruses in children including neonates in Guangzhou, China
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases ; 2022.
Article in English | EuropePMC | ID: covidwho-2147441
ABSTRACT
Background Four seasonal coronaviruses, including HCoV-229E and HCoV-OC43, HCoV-NL63 and HCoV-HKU1 cause approximately 15–30% of common colds in adults. However, the full landscape of the immune trajectory to these viruses that covers the whole childhood period are still not well understood. Methods We evaluated the serological responses against the four seasonal coronaviruses in 1886 children who aged under 18-year-old by using Enzyme-linked immunosorbent assay (ELISA). The O.D values against each human coronavirus were determined from each sample. Generalized addictive models (GAM) were constructed to determine the relationship between the age and seroprevalence throughout the whole childhood period. The specific antibody levels against the four seasonal coronaviruses were also tested from the plasma samples of 485 pairs postpartum women and their newborn babies. Results The IgG levels of the four seasonal coronaviruses in mother and the newborn babies were highly correlated (229E r=0.63;OC43 r=0.65;NL63 r=0.69;HKU1 r=0.63). The seroprevalences in children showed a similar trajectory that the levels of IgG in the neonates dropped significantly and reached to the lowest level after the age of around 1 year (229E 1.18 years;OC43 0.97 years;NL63 1.01 years;HKU1 1.02 years) and then resurgence in the children who aged older than 1 year old. Using the lowest level from the GAMs as our cutoff, the seroprevalences for HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 were 98.11%, 96.23%, 96.23% and 94.34% at the age of 16-18 years. Conclusion Mothers share HCoV-specific IgGs with their newborn babies and the level of maternal IgGs waned at around one year after birth. Resurgence of the HCoV-specific IgGs were found thereafter with the increase of the age suggesting repeated infection occurred in children.
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Collection: Databases of international organizations Database: EuropePMC Type of study: Observational study Language: English Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: EuropePMC Type of study: Observational study Language: English Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Year: 2022 Document Type: Article