Progress in research on human coronavirus and relevant vaccines

ABSTRACT

Coronaviruses (CoVs) are positive-sense and single-strand RNA viruses which have an extensive range of natural hosts and cause respiratory, gastrointestinal, hepatic, renal and neurological diseases of varying severities in livestock, birds and humans.Seven human coronaviruses (HCoVs) have been discovered, of which severe acute respiratory syndrome coronavirus (SAKSCoV), Middle East respiratory snydrome coronavirus (MERSCoV) and 2019 novel coronavirus (2019-nCov) may cause severe fatal pneumonia and have posed a global threat to public health.This paper reviews the progress in research on pathogenicity and vaccines of HCoV. Copyright © 2022 Changchun Institute of Biological Products. All rights reserved.