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Humoral and cellular immunity of two-dose inactivated COVID-19 vaccination in Chinese children: A prospective cohort study.
Wang, Hao; Gan, Mengze; Wu, Bihao; Zeng, Rui; Wang, Zhen; Xu, Jun; Li, Jia; Zhang, Yandi; Cao, Jinge; Chen, Li; Di, Dongsheng; Peng, Siyuan; Lei, Jinfeng; Zhao, Yingying; Song, Xuemei; Yuan, Tingting; Zhou, Tingting; Liu, Qian; Yi, Jing; Wang, Xi; Cai, Hao; Lei, Yanshou; Wen, Yuying; Li, Wenhui; Chen, Qinlin; Wang, Yufei; Long, Pinpin; Yuan, Yu; Wang, Chaolong; Pan, An; Wang, Qi; Gong, Rui; Fan, Xionglin; Wu, Tangchun; Liu, Li.
  • Wang H; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Gan M; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wu B; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
  • Zeng R; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Wang Z; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Xu J; Qichun Center for Disease Control and Prevention, Huanggang, China.
  • Li J; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang Y; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cao J; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen L; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
  • Di D; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Peng S; Qichun Center for Disease Control and Prevention, Huanggang, China.
  • Lei J; Qichun Center for Disease Control and Prevention, Huanggang, China.
  • Zhao Y; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Song X; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Yuan T; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Zhou T; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Liu Q; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Yi J; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Wang X; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Cai H; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Lei Y; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Wen Y; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Li W; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Chen Q; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Wang Y; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Long P; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Yuan Y; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Wang C; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Pan A; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Wang Q; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Gong R; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
  • Fan X; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wu T; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
  • Liu L; Department of Occupational and Environmental Health and Department of Epidemiology and Biostatistics, Ministry of Education and State Key Laboratory of Environmental Health, Huazhong University of Science and Technology, Wuhan, China.
J Med Virol ; 95(1): e28380, 2023 01.
Article in English | MEDLINE | ID: covidwho-2148396
ABSTRACT
Children are the high-risk group for COVID-19, and in need of vaccination. However, humoral and cellular immune responses of COVID-19 vaccine remain unclear in vaccinated children. To establish the rational immunization strategy of inactivated COVID-19 vaccine for children, the immunogenicity of either one dose or two doses of the vaccine in children was evaluated. A prospective cohort study of 322 children receiving inactivated COVID-19 vaccine was established in China. The baseline was conducted after 28 days of the first dose, and the follow-up was conducted after 28 days of the second dose. The median titers of receptor binding domain (RBD)-IgG, and neutralizing antibody (NAb) against prototype strain and Omicron variant after the second dose increased significantly compared to those after the first dose (first dose 70.0, [interquartile range, 30.0-151.0] vs. second dose 1261.0 [636.0-2060.0] for RBD-IgG; 2.5 [2.5-18.6] vs. 252.0 [138.6-462.1] for NAb against prototype strain; 2.5 [2.5-2.5] vs. 15.0 [7.8-26.5] for NAb against Omicron variant, all p < 0.05). The flow cytometry results showed that the first dose elicited SARS-CoV-2 specific cellular immunity, while the second dose strengthened SARS-CoV-2 specific IL-2+ or TNF-α+  monofunctional, IFN-γ+ TNF-α+  bifunctional, and IFN-γ- IL-2+ TNF-α+ multifunctional CD4+ T cell responses (p < 0.05). Moreover, SARS-CoV-2 specific memory T cells were generated after the first vaccination, including the central memory T cells and effector memory T cells. The present findings provide scientific evidence for the vaccination strategy of the inactive vaccines among children against COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Child / Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28380

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Child / Humans Language: English Journal: J Med Virol Year: 2023 Document Type: Article Affiliation country: Jmv.28380