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Flavonoids as a therapeutical option for the treatment of thrombotic complications associated with COVID-19.
Quintal Martínez, Juan Pablo; Segura Campos, Maira Rubi.
  • Quintal Martínez JP; Faculty of Chemical Engineering, Autonomous University of Yucatán, Merida, Mexico.
  • Segura Campos MR; Faculty of Chemical Engineering, Autonomous University of Yucatán, Merida, Mexico.
Phytother Res ; 37(3): 1092-1114, 2023 Mar.
Article in English | MEDLINE | ID: covidwho-2277307
ABSTRACT
The SARS-CoV-2 outbreak has been one of the largest public health crises globally, while thrombotic complications have emerged as an important factor contributing to mortality. Therefore, compounds that regulate the processes involved in thrombosis could represent a dietary strategy to prevent thrombotic complications involved in COVID-19. In August 2022, various databases were consulted using the keywords "flavonoids", "antiplatelet", "anticoagulant", "fibrinolytic", and "nitric oxide". Studies conducted between 2019 and 2022 were chosen. Flavonoids, at concentrations mainly between 2 and 300 µM, are capable of regulating platelet aggregation, blood coagulation, fibrinolysis, and nitric oxide production due to their action on multiple receptors and enzymes. Most of the studies have been carried out through in vitro and in silico models, and limited studies have reported the in vivo and clinical effect of flavonoids. Currently, quercetin has been the only flavonoid evaluated clinically in patients with COVID-19 for its effect on D-dimer levels. Therefore, clinical studies in COVID-19 patients analyzing the effect on platelet, coagulant, fibrinolytic, and nitric oxide parameters are required. In addition, further high-quality studies that consider cytotoxic safety and bioavailability are required to firmly propose flavonoids as a treatment for the thrombotic complications implicated in COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Phytother Res Journal subject: Complementary Therapies Year: 2023 Document Type: Article Affiliation country: Ptr.7700

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Phytother Res Journal subject: Complementary Therapies Year: 2023 Document Type: Article Affiliation country: Ptr.7700