Polymeric-based interface for the development of COVID-19 biosensor

ABSTRACT

Polymeric-based interfaces are inseparable from immobilization strategies and biosensor platforms. They have recently attracted attention as an emerging sensory material due to their easy fabrication, the ability for signal amplification, and convenient nature for detection. Due to their biocompatibility, optical, electrical, and mechanical advantages, polymers have great properties to be utilizedas interface of biosensors. Polymer-based materials have been fabricated in many biosensors such as electrochemical, optical, field-effect transistor, and lateral flow assays. Moreover, high conductive polymer-related materials in the form of composite, gel or beads have been produced to enhance surface to volume ratios and allow different kinds of surface modification with an ease and establish high stability and selectivity. The polymeric materials should be biocompatible and cost-effective. The presence of biopolymers can improve the sensitivity and selectivity of biosensors, which is pivotal for clinical applications. COVID-19 diagnosis can be accelerated by polymer embedded biosensors. In addition, their biodegradable/biocompostable nature will help to lower the burden of COVID-19 pandemic on environment, compared to other polymers, since biosensors are being used heavily during the pandemic. In this chapter, polymer-based approaches are summarized with an emphasis of biopolymers and their composites to be used in COVID-19 biosensors. © 2022 Elsevier Inc. All rights reserved.