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Mortality and Major Adverse Cardiovascular Events in Hospitalized Patients With Atrial Fibrillation With COVID-19.
Wang, Lucas; Hoang, Lawrence; Aten, Kristopher; Abualfoul, Mujahed; Canela, Victor; Prathivada, Sri; Vu, Michael; Zhao, Yi; Sidhu, Manavjot.
  • Wang L; Department of Internal Medicine. Electronic address: lucaswang@mhd.com.
  • Hoang L; Department of Internal Medicine.
  • Aten K; Department of Internal Medicine.
  • Abualfoul M; Department of Internal Medicine.
  • Canela V; Department of Internal Medicine.
  • Prathivada S; Clinical Research Institute, Methodist Dallas Medical Center, Dallas, Texas.
  • Vu M; Department of Internal Medicine.
  • Zhao Y; Department of Internal Medicine.
  • Sidhu M; Methodist Dallas Cardiovascular Consultants, Methodist Medical Group, Division of Cardiology.
Am J Cardiol ; 189: 41-48, 2023 02 15.
Article in English | MEDLINE | ID: covidwho-2149276
ABSTRACT
COVID-19 results in increased incidence of cardiac arrhythmias, including atrial fibrillation (AF). However, little is known about the combined effect of AF and COVID-19 on patient outcomes. This study aimed to determine if AF, specifically new-onset AF (NOAF), is associated with increased risk of mortality and major adverse cardiovascular events (MACEs) in hospitalized patients with COVID-19. This multicenter retrospective analysis identified 2,732 patients with COVID-19 admitted between March and December 2020. Data points were manually reviewed in the patients' electronic health records. Multivariate logistic regression was used to assess if AF was associated with death or MACE. Patients with AF (6.4%) had an increased risk of mortality (risk ratio 2.249, 95% confidence interval [CI] 1.766 to 2.864, p <0.001) and MACE (risk ratio 1.753, 95% CI 1.473 to 2.085, p <0.001) compared with those with sinus rhythm. Patients with NOAF had an increased risk of mortality compared with those with existing AF (odds ratio 19.30, 95% CI 5.39 to 69.30, p <0.001); the risk of MACE was comparable between NOAF and patients with existing AF (p = 1). AF during hospitalization with COVID-19 is associated with a higher risk of mortality and MACE. NOAF in patients with COVID-19 is associated with a higher risk of mortality but a similar risk of MACE compared with patients with existing AF.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atrial Fibrillation / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Humans Language: English Journal: Am J Cardiol Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atrial Fibrillation / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Humans Language: English Journal: Am J Cardiol Year: 2023 Document Type: Article