SnO2 nanoparticles/waste masks carbon hybrid materials for DNA biosensor application on voltammetric detection of anti-cancer drug pazopanib.
Bioelectrochemistry
; 150: 108329, 2023 Apr.
Article
in English
| MEDLINE | ID: covidwho-2149380
ABSTRACT
This present study is the first investigation of pazopanib-dsDNA binding using bare and modified GCE. The interaction was mainly evaluated based on the decrease of voltammetric signal of deoxyadenosine by differential pulse voltammetry using three different ways, including the incubated solutions, dsDNA biosensor, and nanobiosensor. The nanobiosensor was fabricated with the help of SnO2 nanoparticles and carbon hybrid material. The carbon material is derived from the waste mask, the most used personal protective equipment for the ongoing COVID-19 pandemic. Both materials were synthesized via the green synthesis technique and characterized by various techniques, including BET, TEM, SEM-EDX, AFM, XPS, and XRD. Spectrophotometric and molecular docking studies also evaluated the pazopanib-dsDNA binding. All calculations showed that pazopanib (PZB) was active in the minor grove region of DNA.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biosensing Techniques
/
Nanoparticles
/
COVID-19
/
Antineoplastic Agents
Type of study:
Experimental Studies
Limits:
Humans
Language:
English
Journal:
Bioelectrochemistry
Journal subject:
Biochemistry
Year:
2023
Document Type:
Article
Affiliation country:
J.bioelechem.2022.108329
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