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ß-arrestins and G protein-coupled receptor kinases in viral entry: A graphical review.
Maginnis, Melissa S.
  • Maginnis MS; Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, United States of America; Graduate School of Biomedical Science and Engineering, The University of Maine, Orono, ME 04469, United States of America. Electronic address: melissa.maginnis@maine.edu.
Cell Signal ; 102: 110558, 2023 02.
Article in English | MEDLINE | ID: covidwho-2220515
ABSTRACT
Viruses rely on host-cell machinery in order to invade host cells and carry out a successful infection. G-protein coupled receptor (GPCR)-mediated signaling pathways are master regulators of cellular physiological processing and are an attractive target for viruses to rewire cells during infection. In particular, the GPCR-associated scaffolding proteins ß-arrestins and GPCR signaling effectors G-protein receptor kinases (GRKs) have been identified as key cellular factors that mediate viral entry and orchestrate signaling pathways that reprogram cells for viral replication. Interestingly, a broad range of viruses have been identified to activate and/or require GPCR-mediated pathways for infection, including polyomaviruses, flaviviruses, influenza virus, and SARS-CoV-2, demonstrating that these viruses may have conserved mechanisms of host-cell invasion. Thus, GPCR-mediated pathways highlight an attractive target for the development of broad antiviral therapies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: G-Protein-Coupled Receptor Kinases / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Cell Signal Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: G-Protein-Coupled Receptor Kinases / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Cell Signal Year: 2023 Document Type: Article