ß-arrestins and G protein-coupled receptor kinases in viral entry: A graphical review.
Cell Signal
; 102: 110558, 2023 02.
Article
in English
| MEDLINE | ID: covidwho-2220515
ABSTRACT
Viruses rely on host-cell machinery in order to invade host cells and carry out a successful infection. G-protein coupled receptor (GPCR)-mediated signaling pathways are master regulators of cellular physiological processing and are an attractive target for viruses to rewire cells during infection. In particular, the GPCR-associated scaffolding proteins ß-arrestins and GPCR signaling effectors G-protein receptor kinases (GRKs) have been identified as key cellular factors that mediate viral entry and orchestrate signaling pathways that reprogram cells for viral replication. Interestingly, a broad range of viruses have been identified to activate and/or require GPCR-mediated pathways for infection, including polyomaviruses, flaviviruses, influenza virus, and SARS-CoV-2, demonstrating that these viruses may have conserved mechanisms of host-cell invasion. Thus, GPCR-mediated pathways highlight an attractive target for the development of broad antiviral therapies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
G-Protein-Coupled Receptor Kinases
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cell Signal
Year:
2023
Document Type:
Article
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