IFITM3 is a host restriction factor that inhibits porcine transmissible gastroenteritis virus infection.
Vet Microbiol
; 277: 109622, 2023 Feb.
Article
in English
| MEDLINE | ID: covidwho-2150800
ABSTRACT
Interferon-induced transmembrane proteins (IFITMs) play an important role in the innate immune response triggered by viral infection. Transmissible gastroenteritis virus (TGEV) causes severe diarrhea, vomiting and dehydration in piglets, resulting in huge economic losses to the swine industry. In this study, we showed that IFITM3 inhibits the replication of TGEV and interferes with the binding of TGEV to PK15 cells. Moreover, the inhibitory effect of IFITM3 on TGEV circumvents the upregulation of inflammatory cytokines. Subsequently, we found that the M22A mutant loses part of the antiviral effect of IFITM3 on TGEV; in contrast, the K24A mutant enhances the antiviral effect of IFITM3. Notably, our data shows a synergistic effect between IFITM3 and CQ, which further amplifies the antiviral effect against TGEV.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Swine Diseases
/
Transmissible gastroenteritis virus
/
Gastroenteritis, Transmissible, of Swine
Limits:
Animals
Language:
English
Journal:
Vet Microbiol
Year:
2023
Document Type:
Article
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