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Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19).
Alhazzani, Waleed; Møller, Morten Hylander; Arabi, Yaseen M; Loeb, Mark; Gong, Michelle Ng; Fan, Eddy; Oczkowski, Simon; Levy, Mitchell M; Derde, Lennie; Dzierba, Amy; Du, Bin; Aboodi, Michael; Wunsch, Hannah; Cecconi, Maurizio; Koh, Younsuck; Chertow, Daniel S; Maitland, Kathryn; Alshamsi, Fayez; Belley-Cote, Emilie; Greco, Massimiliano; Laundy, Matthew; Morgan, Jill S; Kesecioglu, Jozef; McGeer, Allison; Mermel, Leonard; Mammen, Manoj J; Alexander, Paul E; Arrington, Amy; Centofanti, John E; Citerio, Giuseppe; Baw, Bandar; Memish, Ziad A; Hammond, Naomi; Hayden, Frederick G; Evans, Laura; Rhodes, Andrew.
  • Alhazzani W; Department of Medicine, McMaster University, Hamilton, Canada.
  • Møller MH; Department of Health Research Methods, Evidence, and Impact, McMaster University, Canada.
  • Arabi YM; Copenhagen University Hospital Rigshospitalet, Department of Intensive Care, Copenhagen, Denmark.
  • Loeb M; Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI).
  • Gong MN; Intensive Care Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia.
  • Fan E; Department of Medicine, McMaster University, Hamilton, Canada.
  • Oczkowski S; Department of Health Research Methods, Evidence, and Impact, McMaster University, Canada.
  • Levy MM; Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, New York, USA.
  • Derde L; Interdepartmental Division of Critical Care Medicine and the Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
  • Dzierba A; Department of Medicine, McMaster University, Hamilton, Canada.
  • Du B; Department of Health Research Methods, Evidence, and Impact, McMaster University, Canada.
  • Aboodi M; Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA.
  • Wunsch H; Rhode Island Hospital, Providence, Rhode Island, USA.
  • Cecconi M; Department of Intensive Care Medicine, University medical Center Utrecht, Utrecht University, the Netherlands.
  • Koh Y; Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands.
  • Chertow DS; Department of Pharmacy, New York-Presbyterian Hospital, Columbia University Irving Medical Center, New York, New York, USA.
  • Maitland K; Medical ICU, Peking Union Medical College Hospital, Beijing.
  • Alshamsi F; Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, New York, USA.
  • Belley-Cote E; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Greco M; Department of Anesthesia and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Laundy M; Department of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
  • Morgan JS; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Kesecioglu J; Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • McGeer A; Critical Care Medicine Department, National Institutes of Health Clinical Center and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, USA.
  • Mermel L; Faculty of Medicine, Imperial College, London, UK.
  • Mammen MJ; Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
  • Alexander PE; Department of Medicine, McMaster University, Hamilton, Canada.
  • Arrington A; Population Health Research Institute, Hamilton, Canada.
  • Centofanti JE; Department of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
  • Citerio G; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Baw B; Microbiology and Infection control, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK.
  • Memish ZA; Emory University Hospital, Atlanta, Georgia, USA.
  • Hammond N; Department of Intensive Care Medicine, University medical Center Utrecht, Utrecht University, the Netherlands.
  • Hayden FG; Division of Infectious Diseases, University of Toronto, Toronto, Canada.
  • Evans L; Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA.
  • Rhodes A; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Crit Care Med ; 48(6): e440-e469, 2020 06.
Article in English | MEDLINE | ID: covidwho-2152192
ABSTRACT

BACKGROUND:

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.

METHODS:

We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.

RESULTS:

The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which four are best practice statements, nine are strong recommendations, and 35 are weak recommendations. No recommendation was provided for six questions. The topics were 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy.

CONCLUSION:

The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new evidence in further releases of these guidelines.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Practice Guidelines as Topic / Coronavirus Infections / Intensive Care Units Type of study: Diagnostic study / Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Crit Care Med Year: 2020 Document Type: Article Affiliation country: CCM.0000000000004363

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Practice Guidelines as Topic / Coronavirus Infections / Intensive Care Units Type of study: Diagnostic study / Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Crit Care Med Year: 2020 Document Type: Article Affiliation country: CCM.0000000000004363