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Ontological Analysis of Coronavirus Associated Human Genes at the COVID-19 Disease Portal.
Wang, Shur-Jen; Brodie, Kent C; De Pons, Jeffrey L; Demos, Wendy M; Gibson, Adam C; Hayman, G Thomas; Hill, Morgan L; Kaldunski, Mary L; Lamers, Logan; Laulederkind, Stanley J F; Nalabolu, Harika S; Thota, Jyothi; Thorat, Ketaki; Tutaj, Marek A; Tutaj, Monika; Vedi, Mahima; Zacher, Stacy; Smith, Jennifer R; Dwinell, Melinda R; Kwitek, Anne E.
  • Wang SJ; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Brodie KC; Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • De Pons JL; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Demos WM; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Gibson AC; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Hayman GT; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Hill ML; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Kaldunski ML; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Lamers L; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Laulederkind SJF; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Nalabolu HS; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Thota J; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Thorat K; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Tutaj MA; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Tutaj M; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Vedi M; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Zacher S; Finance and Administration, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Smith JR; The Rat Genome Database, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Dwinell MR; The Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Kwitek AE; The Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Genes (Basel) ; 13(12)2022 12 07.
Article in English | MEDLINE | ID: covidwho-2154948
ABSTRACT
The COVID-19 pandemic stemmed a parallel upsurge in the scientific literature about SARS-CoV-2 infection and its health burden. The Rat Genome Database (RGD) created a COVID-19 Disease Portal to leverage information from the scientific literature. In the COVID-19 Portal, gene-disease associations are established by manual curation of PubMed literature. The portal contains data for nine ontologies related to COVID-19, an embedded enrichment analysis tool, as well as links to a toolkit. Using these information and tools, we performed analyses on the curated COVID-19 disease genes. As expected, Disease Ontology enrichment analysis showed that the COVID-19 gene set is highly enriched with coronavirus infectious disease and related diseases. However, other less related diseases were also highly enriched, such as liver and rheumatic diseases. Using the comparison heatmap tool, we found nearly 60 percent of the COVID-19 genes were associated with nervous system disease and 40 percent were associated with gastrointestinal disease. Our analysis confirms the role of the immune system in COVID-19 pathogenesis as shown by substantial enrichment of immune system related Gene Ontology terms. The information in RGD's COVID-19 disease portal can generate new hypotheses to potentiate novel therapies and prevention of acute and long-term complications of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Reviews Topics: Long Covid Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Genes13122304

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Reviews Topics: Long Covid Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Genes13122304