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Effect of BMI on Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed With COVID-19
Obesity ; 30:286, 2022.
Article in English | ProQuest Central | ID: covidwho-2156689
ABSTRACT

Background:

Obesity has arisen as a prominent risk factor for COVID-19 severity and mortality, potentially owed to an obesity-induced proinflammatory state impacting immune and thrombotic responses. This report characterized the associations between BMI and inflammatory biomarkers in an adult population recently diagnosed with COVID-19 and not hospitalized.

Methods:

These data were derived from a double-blind randomized placebo-controlled clinical trial conducted October 2020-March 2021 (NCT04912921). Participants (N=60) were unvaccinated and reported to the test site following diagnosis as allowed by the CDC's return to work policy. At study baseline and week four, anthropometrics and non-fasting blood samples were collected from participants. We examined the associations between BMI (continuous and categorical) and inflammatory markers via multiple regression models.

Results:

Our analyses revealed significant associations between baseline BMI and IL-6 (ß=0.036, p=0.0001), TNF-α (ß=0.015, p=0.0059), Ferritin (ß=0.018, p=0.0097), C-reactive protein (ß=0.057, p<0.0001), and WBC count (ß=0.104, p=0.0308) adjusting for age, sex, existing conditions, and interval between COVID-19 diagnosis and trial initiation. Analyses of BMI categories revealed similar significant associations between obesity (BMI>30 kg/m2) and elevations in IL-6, CRP, Ferritin, and WBC at baseline (p<0.05). For those individuals in the control group (n=30), after four weeks, an obese BMI was significantly associated with increases in CRP, TNF-α, soluble P-selectin, and ICAM-1 (p<0.05).

Conclusions:

The presence of a hyperinflammatory state is a main driver of the severity of COVID-19, and a suggested link between the increased risk of poor COVID-19 outcomes in individuals with obesity. The present study demonstrated significant associations between BMI and several proinflammatory markers associated with disease severity in an adult population recently diagnosed with COVID-19.
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Collection: Databases of international organizations Database: ProQuest Central Type of study: Experimental Studies Language: English Journal: Obesity Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: ProQuest Central Type of study: Experimental Studies Language: English Journal: Obesity Year: 2022 Document Type: Article