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Low rate of detection of SARS-CoV-2 RNA in deceased tissue donors.
Greenwald, Melissa A; Grebe, Eduard; Green, Valerie; Jones, Alyce Linthurst; Linnen, Jeffrey M; Williamson, Phillip; Busch, Michael P; Kuehnert, Matthew J.
  • Greenwald MA; Donor Alliance, Denver, CO, USA. missygreenwald@gmail.com.
  • Grebe E; Uniformed Services University of the Health Sciences, Bethesda, MD, USA. missygreenwald@gmail.com.
  • Green V; MA Greenwald Consulting, Chicago, IL, USA. missygreenwald@gmail.com.
  • Jones AL; Vitalant Research Institute, San Francisco, CA, USA.
  • Linnen JM; University of California San Francisco, San Francisco, CA, USA.
  • Williamson P; DSI-NRF Centre of Excellence in Epidemiological Modelling and Analysis, Stellenbosch University, Stellenbosch, South Africa.
  • Busch MP; Creative Testing Solutions, Tempe, AZ, USA.
  • Kuehnert MJ; LifeNet Health, Virginia Beach, VA, USA.
Cell Tissue Bank ; 2022 Dec 09.
Article in English | MEDLINE | ID: covidwho-2158085
ABSTRACT
Given the possibility for disease transmission, this study was performed to determine whether there is detectable SARS-CoV-2 viral RNA in the blood of deceased tissue donors. A retrospective analysis of blood samples from eligible deceased tissue donors from Oct 2019 through June 2020 was performed. Plasma aliquots were initially tested with a SARS-CoV-2 NAT Assay; positive samples were further tested using an alternate NAT and an antibody assay. The proportion of donors with confirmed RNAemia and 95% confidence intervals were computed. Of donor samples collected in 2019, 894 yielded valid results, with 6 initially positive, none of which confirmed positive by alternate NAT. Of donor samples collected in 2020, 2562 yielded valid initial NAT results, with 21 (0.8%) initially positive. Among those, 3 were confirmed by alternate NAT, 17 were not confirmed, and 1 had an invalid alternate NAT result. The rate of SARS-CoV-2 RNAemia in deceased tissue donors is approximately 1 per 1000, and it is unknown whether this RNAemia reflects the presence of infectious virus. Given these results, the risk of transmission through tissue is thought likely to be low.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal subject: Histology / Transplantation Year: 2022 Document Type: Article Affiliation country: S10561-022-10054-0

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal subject: Histology / Transplantation Year: 2022 Document Type: Article Affiliation country: S10561-022-10054-0