Your browser doesn't support javascript.
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19.
Khoo, Weng Hua; Jackson, Katherine; Phetsouphanh, Chansavath; Zaunders, John J; Alquicira-Hernandez, José; Yazar, Seyhan; Ruiz-Diaz, Stephanie; Singh, Mandeep; Dhenni, Rama; Kyaw, Wunna; Tea, Fiona; Merheb, Vera; Lee, Fiona X Z; Burrell, Rebecca; Howard-Jones, Annaleise; Koirala, Archana; Zhou, Li; Yuksel, Aysen; Catchpoole, Daniel R; Lai, Catherine L; Vitagliano, Tennille L; Rouet, Romain; Christ, Daniel; Tang, Benjamin; West, Nicholas P; George, Shane; Gerrard, John; Croucher, Peter I; Kelleher, Anthony D; Goodnow, Christopher G; Sprent, Jonathan D; Powell, Joseph E; Brilot, Fabienne; Nanan, Ralph; Hsu, Peter S; Deenick, Elissa K; Britton, Philip N; Phan, Tri Giang.
  • Khoo WH; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Jackson K; Garvan Institute of Medical Research, Sydney, Australia.
  • Phetsouphanh C; Kirby Institute, UNSW Sydney, Sydney, Australia.
  • Zaunders JJ; Centre for Applied Medical Research, St Vincent's Hospital, Sydney, Australia.
  • Alquicira-Hernandez J; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, Australia; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
  • Yazar S; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, Australia.
  • Ruiz-Diaz S; Garvan Institute of Medical Research, Sydney, Australia.
  • Singh M; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Dhenni R; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Kyaw W; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Tea F; Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Merheb V; Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Lee FXZ; Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia.
  • Burrell R; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
  • Howard-Jones A; Kids Research, The Children's Hospital at Westmead, Sydney, Australia.
  • Koirala A; Kids Research, The Children's Hospital at Westmead, Sydney, Australia.
  • Zhou L; Kids Research, The Children's Hospital at Westmead, Sydney, Australia.
  • Yuksel A; Kids Research, The Children's Hospital at Westmead, Sydney, Australia.
  • Catchpoole DR; Kids Research, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Child and Adolescent Health, The University of Sydney, Sydney, Australia.
  • Lai CL; Kids Research, The Children's Hospital at Westmead, Sydney, Australia.
  • Vitagliano TL; Kids Research, The Children's Hospital at Westmead, Sydney, Australia.
  • Rouet R; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Christ D; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Tang B; Department of Intensive Care Medicine, Nepean Hospital, Sydney, Australia; Centre for Immunology and Allergy Research, The Westmead Institute for Medical Research, Sydney, Australia; Respiratory Tract Infection Research Node, Marie Bashir Institute for Infectious Diseases and Biosecurity, Sydney, Au
  • West NP; Systems Biology and Data Science, Menzies Health Institute QLD, Griffith University, Parklands, Australia.
  • George S; Departments of Emergency Medicine and Children's Critical Care, Gold Coast University Hospital, Southport, QLD, Australia; School of Medicine and Menzies Health Institute Queensland, Griffith University, Southport, QLD, Australia.
  • Gerrard J; Department of Infectious Diseases and Immunology, Gold Coast University Hospital, Southport, QLD, Australia.
  • Croucher PI; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Kelleher AD; Kirby Institute, UNSW Sydney, Sydney, Australia.
  • Goodnow CG; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia; UNSW Cellular Genomics Futures Institute, UNSW Sydney, Sydney, Australia.
  • Sprent JD; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Powell JE; Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, Sydney, Australia; UNSW Cellular Genomics Futures Institute, UNSW Sydney, Sydney, Australia.
  • Brilot F; Brain Autoimmunity Group, Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, Sydney, Australia; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, Australia; Brain and Mind Centre, The University of Sydney, Sydney, Australia.
  • Nanan R; Charles Perkins Centre Nepean, University of Sydney, Sydney, Australia.
  • Hsu PS; Kids Research, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Child and Adolescent Health, The University of Sydney, Sydney, Australia.
  • Deenick EK; Garvan Institute of Medical Research, Sydney, Australia; Faculty of Medicine, UNSW Sydney, Sydney, Australia.
  • Britton PN; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; The Children's Hospital at Westmead, Sydney Children's Hospitals Network, Sydney, Australia.
  • Phan TG; Garvan Institute of Medical Research, Sydney, Australia; St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia. Electronic address: t.phan@garvan.org.au.
Clin Immunol ; 246: 109209, 2023 01.
Article in English | MEDLINE | ID: covidwho-2158591
ABSTRACT
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced immunity are beginning to be uncovered. We show by longitudinal multimodal analysis that SARS-CoV-2 leaves a small footprint in the circulating T cell compartment in children with mild/asymptomatic COVID-19 compared to adult household contacts with the same disease severity who had more evidence of systemic T cell interferon activation, cytotoxicity and exhaustion. Children harbored diverse polyclonal SARS-CoV-2-specific naïve T cells whereas adults harbored clonally expanded SARS-CoV-2-specific memory T cells. A novel population of naïve interferon-activated T cells is expanded in acute COVID-19 and is recruited into the memory compartment during convalescence in adults but not children. This was associated with the development of robust CD4+ memory T cell responses in adults but not children. These data suggest that rapid clearance of SARS-CoV-2 in children may compromise their cellular immunity and ability to resist reinfection.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Adult / Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: J.clim.2022.109209

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Adult / Humans Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2023 Document Type: Article Affiliation country: J.clim.2022.109209