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SARS-CoV-2 infection among healthcare workers whom already received booster vaccination during epidemic outbreak of omicron variant in Taiwan.
Sheng, Wang-Huei; Chang, Hao-Chun; Chang, Sui-Yuan; Hsieh, Ming-Ju; Chen, Yu-Cheng; Wu, Yu-Yun; Pan, Sung-Ching; Wang, Jann-Tay; Chen, Yee-Chun.
  • Sheng WH; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan. Electronic address: whsheng@ntu.edu.tw.
  • Chang HC; Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu County, Taiwan.
  • Chang SY; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
  • Hsieh MJ; Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan; Occupational Safety and Health Office, National Taiwan University Hospital, Taipei, Taiwan.
  • Chen YC; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
  • Wu YY; Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Pan SC; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; Infection Control Center, National Taiwan University Hospital, Taipei, Taiwan.
  • Wang JT; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan.
  • Chen YC; Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; Infection Control Center, National Taiwan University Hospital, Taipei, Taiwan.
J Formos Med Assoc ; 122(5): 376-383, 2023 May.
Article in English | MEDLINE | ID: covidwho-2303630
ABSTRACT
BACKGROUND/

PURPOSE:

Healthcare workers (HCWs) are at risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection due to occupational exposure. We aim to investigate the prevalence and risk factors of SARS-CoV-2 infection among HCWs during epidemic outbreak of omicron variant in Taiwan.

METHODS:

Sequential reserved serum samples collected from our previous study during December 2021 and July 2022 were tested for antibodies against SARS-CoV-2 nucleocapsid protein (NP). Diagnosis of SARS-CoV-2 infection was defined as positive either of anti-SARS-CoV-2 nucleoprotein, rapid antigen test or polymerase chain reaction. Retrospective chart review and a questionnaire were used to access the symptoms and risk factors for SARS-CoV-2 infection.

RESULTS:

Totally 300 participants (69.3% female) with a median age of 37.9 years were enrolled. A significant increase incidence of SARS-CoV-2 infection was found before and during community outbreak (11.91 versus 230.93 per 100,000 person-days, P < 0.001), which was a trend paralleling that observed in the general population. For 61 SARS-CoV-2 infected participants, nine (14.8%) were asymptomatic. Multivariate analysis revealed recent contact with a SARS-CoV-2 infected household (odds ratio [OR], 7.01; 95% confidence interval [95% CI], 3.70-13.30; P < 0.001) and co-existed underlying autoimmune diseases (OR, 4.46; 95% CI, 1.28-15.51; P = 0.019) were significant risk factors associated with acquisition of SARS-CoV-2 infection among HCWs.

CONCLUSION:

Community factors, such as closely contact with SARS-CoV-2 infected individuals and underlying immune suppression status, were significant factors for acquisition of SARS-CoV-2 infection among HCWs. We suggest the application of appropriate infection control measures for HCWs should be maintained to reduce risk of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: J Formos Med Assoc Journal subject: Medicine Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: J Formos Med Assoc Journal subject: Medicine Year: 2023 Document Type: Article