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Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study.
Russo, Antonio; Pisaturo, Mariantonietta; De Luca, Ilaria; Schettino, Ferdinando; Maggi, Paolo; Numis, Fabio Giuliano; Gentile, Ivan; Sangiovanni, Vincenzo; Rossomando, Anna Maria; Gentile, Valeria; Calabria, Giosuele; Rescigno, Caroliona; Megna, Angelo Salomone; Masullo, Alfonso; Manzillo, Elio; Russo, Grazia; Parrella, Roberto; Dell'Aquila, Giuseppina; Gambardella, Michele; Ponticiello, Antonio; Reginelli, Alfonso; Coppola, Nicola.
  • Russo A; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", Napoli, Italy.
  • Pisaturo M; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", Napoli, Italy.
  • De Luca I; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", Napoli, Italy.
  • Schettino F; Radiology Unit, Departement of Precision Medicine, University of Campania "L. Vanvitelli", Napoli, Italy.
  • Maggi P; Infectious Diseases Unit, A.O. S Anna e S Sebastiano Caserta, Italy.
  • Numis FG; Emergency unit, PO Santa Maria delle Grazie, Pozzuoli, Italy.
  • Gentile I; Infectious disease unit; University Federico II, Naples, Italy.
  • Sangiovanni V; Third Infectious Diseases Unit, AORN dei Colli, P.O. Cotugno, Naples, Italy.
  • Rossomando AM; IV Infectious Disease Unit, AORN dei Coli, PO Cotugno, Naples, Italy.
  • Gentile V; Hepatic Infectious Disease Unit, AORN dei Colli, PO Cotugno, Naples, Italy.
  • Calabria G; IX Infectious Disease Unit, AORN dei Coli, PO Cotugno, Naples, Italy.
  • Rescigno C; First Infectious Disease Unit, AORN dei Coli, PO Cotugno, Naples, Italy.
  • Megna AS; Infectious Diseease Unit, A.O. San Pio, PO Rummo, Benevento, Italy.
  • Masullo A; Infectious disease unit, A.O. San Giovanni di Dio e Ruggi D'Aragona Salerno, Italy.
  • Manzillo E; VIII Infectious Disease Unit, AORN dei Coli, PO Cotugno, Naples, Italy.
  • Russo G; Infectious Disease Unit, Ospedale Maria S.S. Addolorata di Eboli, ASL Salerno, Italy.
  • Parrella R; Respiratory Infectious Diseases Unit, AORN dei Colli, PO Cotugno, Naples, Italy.
  • Dell'Aquila G; Infectious Diseases Unit, AO Avellino, Italy.
  • Gambardella M; Infectious Diseease Unit, PO S. Luca, Vallo della Lucania, ASL Salerno, Italy.
  • Ponticiello A; Pneumology Unit, AORN Caserta, Italy.
  • Reginelli A; Radiology Unit, Departement of Precision Medicine, University of Campania "L. Vanvitelli", Napoli, Italy.
  • Coppola N; Infectious Diseases, Department of Mental Health and Public Medicine, University of Campania "L. Vanvitelli", Napoli, Italy. Electronic address: nicola.coppola@unicampania.it.
J Infect Public Health ; 16(1): 136-142, 2023 Jan.
Article in English | MEDLINE | ID: covidwho-2159300
ABSTRACT

INTRODUCTION:

Since the beginning of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic an important tool for patients with Coronavirus Disease 2019 (COVID-19) has been the computed tomography (CT) scan, but not always available in some settings The aim was to find a cut-off that can predict worsening in patients with COVID-19 assessed with a computed tomography (CT) scan and to find laboratory, clinical or demographic parameters that may correlate with a higher CT score.

METHODS:

We performed a multi-center, observational, retrospective study involving seventeen COVID-19 Units in southern Italy, including all 321 adult patients hospitalized with a diagnosis of COVID-19 who underwent at admission a CT evaluated using Pan score.

RESULTS:

Considering the clinical outcome and Pan score, the best cut-off point to discriminate a severe outcome was 12.5. High lactate dehydrogenase (LDH) serum value and low PaO2/FiO2 ratio (P/F) resulted independently associated with a high CT score. The Area Under Curve (AUC) analysis showed that the best cut-off point for LDH was 367.5 U/L and for P/F 164.5. Moreover, the patients with LDH> 367.5 U/L and P/F < 164.5 showed more frequently a severe CT score than those with LDH< 367.5 U/L and P/F> 164.5, 83.4%, vs 20%, respectively.

CONCLUSIONS:

A direct correlation was observed between CT score value and outcome of COVID-19, such as CT score and high LDH levels and low P/F ratio at admission. Clinical or laboratory tools that predict the outcome at admission to hospital are useful to avoiding the overload of hospital facilities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2023 Document Type: Article Affiliation country: J.jiph.2022.12.009

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2023 Document Type: Article Affiliation country: J.jiph.2022.12.009