Your browser doesn't support javascript.
Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation.
Jeong, Gi Uk; Kwon, Hyung-Jun; Ng, Wern Hann; Liu, Xiang; Moon, Hyun Woo; Yoon, Gun Young; Shin, Hye Jin; Lee, In-Chul; Ling, Zheng Lung; Spiteri, Alanna G; King, Nicholas J C; Taylor, Adam; Chae, Ji Soo; Kim, Chonsaeng; Ahn, Dae-Gyun; Kim, Kyun-Do; Ryu, Young Bae; Kim, Seong-Jun; Mahalingam, Suresh; Kwon, Young-Chan.
  • Jeong GU; Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Kwon HJ; Department of Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Republic of Korea.
  • Ng WH; Center for Companion Animal New Drug Development, Jeonbuk Branch, Korea Institute of Toxicology, Jeongeup, 53212, Republic of Korea.
  • Liu X; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
  • Moon HW; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.
  • Yoon GY; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia.
  • Shin HJ; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
  • Lee IC; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.
  • Ling ZL; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia.
  • Spiteri AG; Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • King NJC; Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Taylor A; Department of Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
  • Chae JS; Department of Microbiology, Chungnam National University School of Medicine, Daejeon, 35015, Republic of Korea.
  • Kim C; Department of Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Republic of Korea.
  • Ahn DG; Center for Companion Animal New Drug Development, Jeonbuk Branch, Korea Institute of Toxicology, Jeongeup, 53212, Republic of Korea.
  • Kim KD; Viral Immunopathology Laboratory, The Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Ryu YB; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Kim SJ; Viral Immunopathology Laboratory, The Charles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Mahalingam S; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
  • Kwon YC; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.
Nat Commun ; 13(1): 7675, 2022 12 12.
Article in English | MEDLINE | ID: covidwho-2160208
ABSTRACT
Although ocular manifestations are reported in patients with COVID-19, consensus on ocular tropism of SARS-CoV-2 is lacking. Here, we infect K18-hACE2 transgenic mice with SARS-CoV-2 using various routes. We observe ocular manifestation and retinal inflammation with production of pro-inflammatory cytokines in the eyes of intranasally (IN)-infected mice. Intratracheal (IT) infection results in dissemination of the virus from the lungs to the brain and eyes via trigeminal and optic nerves. Ocular and neuronal invasions are confirmed using intracerebral (IC) infection. Notably, the eye-dropped (ED) virus does not cause lung infection and becomes undetectable with time. Ocular and neurotropic distribution of the virus in vivo is evident in fluorescence imaging with an infectious clone of SARS-CoV-2-mCherry. The ocular tropic and neuroinvasive characteristics of SARS-CoV-2 are confirmed in wild-type Syrian hamsters. Our data can improve the understanding regarding viral transmission and clinical characteristics of SARS-CoV-2 and help in improving COVID-19 control procedures.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article