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Population-based sero-epidemiological investigation of the dynamics of SARS-CoV-2 infections in the Greater Accra Region of Ghana.
Mensah, Benedicta Ayiedu; Ndong, Ignatius Cheng; Quashie, Peter Kojo; Guichet, Emilande; Abuaku, Benjamin; Effah-Baafi, Yaw; Tapela, Kesego; Asiedu, Kwame; Appiedu-Addo, Sekyibea Nana Ama; Obbeng, Louisa Baaba; Amponsah, Jones Amo; Kusi, Kwadwo Asamoah; Ofori, Michael; Ayouba, Ahidjo; Courtin, David; Tahar, Rachida; Delaporte, Eric; Awandare, Gordon; Ndam, Nicaise Tuikue.
  • Mensah BA; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. bmensah@noguchi.ug.edu.gh.
  • Ndong IC; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Quashie PK; Department of Biochemistry, Catholic University of Cameroon, Bamenda, Cameroon.
  • Guichet E; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana.
  • Abuaku B; TransVIHMI, University of Montpellier, IRD and Institut National de La Santé Et de La Recherche Médicale (INSERM), Montpellier, France.
  • Effah-Baafi Y; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Tapela K; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Asiedu K; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana.
  • Appiedu-Addo SNA; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana.
  • Obbeng LB; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana.
  • Amponsah JA; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana.
  • Kusi KA; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Ofori M; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Ayouba A; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Courtin D; TransVIHMI, University of Montpellier, IRD and Institut National de La Santé Et de La Recherche Médicale (INSERM), Montpellier, France.
  • Tahar R; MERIT, IRD, Université de Paris, 75006, Paris, France.
  • Delaporte E; MERIT, IRD, Université de Paris, 75006, Paris, France.
  • Awandare G; TransVIHMI, University of Montpellier, IRD and Institut National de La Santé Et de La Recherche Médicale (INSERM), Montpellier, France.
  • Ndam NT; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Accra, Ghana.
Sci Rep ; 12(1): 21582, 2022 12 14.
Article in English | MEDLINE | ID: covidwho-2160317
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic devastated countries worldwide, and resulted in a global shutdown. Not all infections are symptomatic and hence the extent of SARS-CoV-2 infection in the community is unknown. The paper presents the dynamics of the SARS-CoV-2 epidemic in the Greater Accra Metropolis, describing the evolution of seroprevalence through time and by age group. Three repeated independent population-based surveys at 6-week intervals were conducted in from November 2020 to July 2021. The global and by age-groups weighted seroprevalences were estimated and the risk factors for SARS-CoV-2 antibody seropositivity were assessed using logistic regression. The overall age-standardized SARS-CoV-2 antibody seroprevalence for both spike and nucleocapsid increased from 13.8% (95% CI 11.9, 16.1) in November 2020 to 39.6% (95% CI 34.8, 44.6) in July 2021. After controlling for gender, marital status, education level, and occupation, the older age group over 40 years had a higher odds of seropositivity than the younger age group (OR 3.0 [95% CI 1.1-8.5]) in the final survey. Pupils or students had 3.3-fold increased odds of seropositivity (OR 3.2 [95% CI 1.1-8.5]) compared to the unemployed. This study reinforces that, SARS-CoV-2 infections have been significantly higher than reported.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Humans Country/Region as subject: Africa Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-25598-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Humans Country/Region as subject: Africa Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-25598-0