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At-home telespirometry (AHT) in amyotrophic lateral sclerosis (ALS): Digital health technology and quality control
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration ; 23(Supplement 1):189, 2022.
Article in English | EMBASE | ID: covidwho-2160824
ABSTRACT

Background:

Smart phone mobile application (Breathe Easy app) with data dashboard (https//www.zephyrx.com/) receive and display results of remote FVC accelerated in use during COVID-19 pandemic. Objective(s) We assessed the reliability of FVC as reported with in-clinic Conventional (Viaire and Vyasis, USA) and inclinic portable and at-home portable (MIR Spirobank Smart, Italy) spirometers that calculated FVC as percentage of predicted values based on GLI (Global Lung Index)-2012 reference standard. Method(s) In this retrospective study, twenty-two ALS patients were analyzed from a total of 95 ALS patients seen in clinic between July 2020 and June 2021. Independent analysis of FVC % predicted values acquired with portable spirometer was performed using GLI-2012 online calculator equations based on age, height, gender and ethnicity. To confirm that the same reference standard GLI-2012 was displayed by the software application, a web-based tool was used to calculate % predicted FVC to confirm that spirometric values were standardized according to GLI-2012 (glicalculator. ersnet.org). Result(s) A third of dashboard-reported measurements were found to be 1% less than calculated measurements (29 out of 87 portable spirometry measurements) and appeared to be a fairly consistent difference in the first 1/3 of FVC followed longitudinally. Query was brought to the attention of the ZephyRx software development team. Dashboard algorithm was assessed to investigate for possible systematic error to account for the difference. The automated dashboard reporting of age using exact birth date to one decimal place on the day of testing as opposed to birth year used with manual calculations was confirmed to result in the 1% predicted difference in manually calculated FVC. Discussion(s) Reported difference in spirometric values can be due to systematic difference in spirometric reference standards or a true difference in pulmonary function (1). ALS-specific digital health technology require vetting by independent ALS neuromuscular and pulmonary researchers and quality testing needs to occur within the clinical realm (2).
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Year: 2022 Document Type: Article