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Prophylactic Administration of the Monoclonal Antibody Adintrevimab Protects against SARS-CoV-2 in Hamster and Non-Human Primate Models of COVID-19.
Zumbrun, Elizabeth E; Kaku, Chengzi I; Dillinger, Lukas; Zak, Samantha E; Kuehne, Ana I; Bakken, Russel R; Koehler, Jeffrey W; Delp, Korey L; Stefan, Christopher P; Kumar, Raina; Kugelman, Jeffrey R; Moreau, Alicia M; Zeng, Xiankun; Dye, John M; Herbert, Andrew S; Narayan, Kristin; Walker, Laura M.
  • Zumbrun EE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Kaku CI; Adimab LLC, Lebanon, New Hampshire, USA.
  • Dillinger L; Invivyd, Inc., Waltham, Massachusetts, USA.
  • Zak SE; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Kuehne AI; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Bakken RR; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Koehler JW; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Delp KL; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Stefan CP; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Kumar R; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Kugelman JR; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Moreau AM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Zeng X; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Dye JM; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Herbert AS; U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA.
  • Narayan K; Invivyd, Inc., Waltham, Massachusetts, USA.
  • Walker LM; Invivyd, Inc., Waltham, Massachusetts, USA.
Antimicrob Agents Chemother ; 67(1): e0135322, 2023 01 24.
Article in English | MEDLINE | ID: covidwho-2161793
ABSTRACT
Adintrevimab is a human immunoglobulin G1 monoclonal antibody engineered to have broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and other SARS-like coronaviruses with pandemic potential. In both Syrian golden hamster and rhesus macaque models, prophylactic administration of a single dose of adintrevimab provided protection against SARS-CoV-2/WA1/2020 infection in a dose-dependent manner, as measured by significant reductions in lung viral load and virus-induced lung pathology, and by inhibition of viral replication in the upper and lower respiratory tract.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Antimicrob Agents Chemother Year: 2023 Document Type: Article Affiliation country: Aac.01353-22

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Antimicrob Agents Chemother Year: 2023 Document Type: Article Affiliation country: Aac.01353-22