IgA vasculitis presenting as nephrotic syndrome following COVID-19 vaccination: a case report.
BMC Nephrol
; 23(1): 403, 2022 12 15.
Article
in English
| MEDLINE | ID: covidwho-2162316
ABSTRACT
BACKGROUND:
Following the strong recommendation for coronavirus disease 2019 (COVID19) vaccination, many patients with medical comorbidities are being immunized. However, the safety of vaccination in patients with autoimmune diseases has not been well established. We report a new case of biopsy-proven IgA vasculitis with nephritis presenting as a nephrotic syndrome after mRNA COVID-19 vaccination in a patient with a history of leukocytoclastic vasculitis. CASE PRESENTATION A 76-year-old man with a history of cutaneous leukocytoclastic vasculitis presented with purpura in both lower limbs, followed by nephrotic syndrome after the second dose of BNT162b2 mRNA COVID-19 vaccination. Skin and renal biopsy revealed IgA vasculitis with nephritis. The patient's past medical history of leukocytoclastic vasculitis and features of chronicity in renal pathology suggest an acute exacerbation of preexisting IgA vasculitis after COVID-19 vaccination. After the steroid and renin-angiotensin system inhibitor use, purpura and acute kidney injury recovered within a month. Subnephrotic proteinuria with microscopic hematuria remained upon follow-up.CONCLUSION:
Physicians should keep in mind the potential (re)activation of IgA vasculitis following mRNA COVID-19 vaccines. It is important to closely monitor COVID-19 vaccinated patients, particularly those with autoimmune diseases.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
IgA Vasculitis
/
COVID-19 Vaccines
Type of study:
Case report
/
Cohort study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
BMC Nephrol
Journal subject:
Nephrology
Year:
2022
Document Type:
Article
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