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Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells.
Nikesjö, Frida; Sayyab, Shumaila; Karlsson, Lovisa; Apostolou, Eirini; Rosén, Anders; Hedman, Kristofer; Lerm, Maria.
  • Nikesjö F; Department of Respiratory Medicine in Linköping, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Sayyab S; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Campus US, Medical Microbiology, Lab1, Floor 12, 581 85, Linköping, Sweden. shumaila.sayyab@liu.se.
  • Karlsson L; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Campus US, Medical Microbiology, Lab1, Floor 12, 581 85, Linköping, Sweden.
  • Apostolou E; Division of Cell Biology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Rosén A; Division of Cell Biology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Hedman K; Department of Clinical Physiology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
  • Lerm M; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University, Campus US, Medical Microbiology, Lab1, Floor 12, 581 85, Linköping, Sweden. maria.lerm@liu.se.
Clin Epigenetics ; 14(1): 172, 2022 12 14.
Article in English | MEDLINE | ID: covidwho-2162416
ABSTRACT
Post-acute COVID-19 syndrome (PACS) has been defined as symptoms persisting after clearance of a COVID-19 infection. We have previously demonstrated that alterations in DNA methylation (DNAm) status persist in individuals who recovered from a COVID-19 infection, but it is currently unknown if PACS is associated with epigenetic changes. We compared DNAm patterns in patients with PACS with those in controls and in healthy COVID-19 convalescents and found a unique DNAm signature in PACS patients. This signature unravelled modified pathways that regulate angiotensin II and muscarinic receptor signalling and protein-protein interaction networks that have bearings on vesicle formation and mitochondrial function.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukocytes, Mononuclear / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: Clin Epigenetics Year: 2022 Document Type: Article Affiliation country: S13148-022-01398-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukocytes, Mononuclear / COVID-19 Topics: Long Covid Limits: Humans Language: English Journal: Clin Epigenetics Year: 2022 Document Type: Article Affiliation country: S13148-022-01398-1