Your browser doesn't support javascript.
Potential therapeutic value of necroptosis inhibitor for the treatment of COVID-19.
Kang, Yongan; Wang, Qinghai.
  • Kang Y; Cardiovascular Medicine, The Second People's Hospital Affiliated to Three Gorges University/Yichang Second People's Hospital, Yichang, 443000, China.
  • Wang Q; Three Gorges University College of Basic Medicine, Yichang, 443000, China.
Eur J Med Res ; 27(1): 283, 2022 Dec 09.
Article in English | MEDLINE | ID: covidwho-2162425
ABSTRACT
The coronavirus disease 2019 (COVID-19), caused by a novel virus of the beta-coronavirus genus (SARS-CoV-2), has spread rapidly, posing a significant threat to global health. There are currently no drugs available for effective treatment. Severe cases of COVID-19 are associated with hyperinflammation, also known as cytokine storm syndrome. The reduce inflammation are considered promising treatments for COVID-19. Necroptosis is a type of programmed necrosis involved in immune response to viral infection, and severe inflammatory injury. Inhibition of necroptosis is pivotal in preventing associated inflammatory responses. The expression of key regulators of the necroptosis pathway is generally up-regulated in COVID-19, indicating that the necroptosis pathway is activated. Thus, necroptosis inhibitors are expected to be novel therapeutic candidates for the treatment of COVID-19.Better knowledge of the necroptosis pathway mechanism is urgently required to solve the remaining mysteries surrounding the role of necroptosis in COVID-19. In this review, we briefly introduce the pathogenesis of necroptosis, the relationship between necroptosis, cytokine storm, and COVID-19 also summarizes the progress of inhibitors of necroptosis. This research provides a timely and necessary suggest of the development of necroptosis inhibitors to treat COVID-19 and clinical transformation of inhibitors of necroptosis.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Med Res Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: S40001-022-00913-7

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Eur J Med Res Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: S40001-022-00913-7