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Association of Obesity and Diabetes with SARS-Cov-2 Infection and Symptoms in the COVID-19 Community Research Partnership.
Mongraw-Chaffin, Morgana; Tjaden, Ashley Hogan; Seals, Austin Lyles; Miller, Kristen; Ahmed, Naheed; Espeland, Mark A; Gibbs, Michael; Thomas, Dorey; Uschner, Diane; Weintraub, William S; Edelstein, Sharon L.
  • Mongraw-Chaffin M; Wake Forest School of Medicine, Winston-Salem, NC.
  • Tjaden AH; The Biostatistics Center, George Washington University, Rockville, Maryland.
  • Seals AL; Wake Forest School of Medicine, Winston-Salem, NC.
  • Miller K; MedStar Health Research Institute, Georgetown University Washington, District of Columbia.
  • Ahmed N; NYU Grossman School of Medicine, New York, NY.
  • Espeland MA; Wake Forest School of Medicine, Winston-Salem, NC.
  • Gibbs M; Atrium Health, Charlotte, NC, USA.
  • Thomas D; Wake Forest School of Medicine, Winston-Salem, NC.
  • Uschner D; The Biostatistics Center, George Washington University, Rockville, Maryland.
  • Weintraub WS; MedStar Health Research Institute, Georgetown University Washington, District of Columbia.
  • Edelstein SL; The Biostatistics Center, George Washington University, Rockville, Maryland.
J Clin Endocrinol Metab ; 2022 Dec 09.
Article in English | MEDLINE | ID: covidwho-2162472
ABSTRACT

OBJECTIVE:

Obesity and diabetes are established risk factors for severe SARS-CoV-2 outcomes, but less is known about their impact on susceptibility to COVID-19 infection and general symptom severity. We hypothesized that those with obesity or diabetes would be more likely to self-report a positive SARS-CoV-2 test, and among those with a positive test, have greater symptom severity and duration.

METHODS:

Among 44,430 COVID-19 Community Research Partnership participants, we evaluated the association of self-reported and electronic health record obesity and diabetes with a self-reported positive COVID-19 test at any time. Among the 2,663 participants with a self-reported positive COVID-19 test during the study, we evaluated the association of obesity and diabetes with self-report of symptom severity, duration, and hospitalization. Logistic regression models were adjusted for age, sex, race/ethnicity, socioeconomic status, and healthcare worker status.

RESULTS:

We found a positive graded association between Body Mass Index (BMI) category and positive COVID-19 test (Overweight OR = 1.14 [1.05-1.25]; Obesity I OR = 1.29 [1.17-2.42]; Obesity II OR = 1.34 [1.19-1.50]; Obesity III OR = 1.53 [1.35-1.73]), and a similar but weaker association with COVID-19 symptoms and severity among those with a positive test. Diabetes was associated with COVID-19 infection but not symptoms after adjustment, with some evidence of an interaction between obesity and diabetes.

CONCLUSIONS:

While the limitations of this health system convenience sample include generalizability and selection around test-seeking, the strong graded association of BMI and diabetes with self-reported COVID-19 infection suggests that obesity and diabetes may play a role in risk for symptomatic SARS-CoV-2 beyond co-occurrence with socioeconomic factors.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Clinem

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Clinem