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High-flow nasal oxygen in acute hypoxemic respiratory failure: A narrative review of the evidence before and after the COVID-19 pandemic.
Genecand, Léon; Agoritsas, Thomas; Ehrensperger, Charlotte; Kharat, Aileen; Marti, Christophe.
  • Genecand L; Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.
  • Agoritsas T; Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Ehrensperger C; Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland.
  • Kharat A; Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Marti C; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Front Med (Lausanne) ; 9: 1068327, 2022.
Article in English | MEDLINE | ID: covidwho-2163048
ABSTRACT
High-flow nasal oxygen (HFNO) is a type of non-invasive advanced respiratory support that allows the delivery of high-flow and humidified air through a nasal cannula. It can deliver a higher inspired oxygen fraction than conventional oxygen therapy (COT), improves secretion clearance, has a small positive end-expiratory pressure, and exhibits a washout effect on the upper air space that diminishes dead space ventilation. HFNO has been shown to reduce the work of breathing in acute hypoxemic respiratory failure (AHRF) and has become an interesting option for non-invasive respiratory support. Evidence published before the COVID-19 pandemic suggested a possible reduction of the need for invasive mechanical ventilation compared to COT. The COVID-19 pandemic has resulted in a substantial increase in AHRF worldwide, overwhelming both acute and intensive care unit capacity in most countries. This triggered new trials, adding to the body of evidence on HFNO in AHRF and its possible benefits compared to COT or non-invasive ventilation. We have summarized and discussed this recent evidence to inform the best supportive strategy in AHRF both related and unrelated to COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Reviews Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.1068327

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Reviews Language: English Journal: Front Med (Lausanne) Year: 2022 Document Type: Article Affiliation country: Fmed.2022.1068327