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Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia.
Dzhaubermezov, Murat; Ekomasova, Natalya; Mustafin, Rustam; Gabidullina, Lilia; Galimova, Yuliya; Nurgalieva, Alfiya; Valova, Yana; Prokofyeva, Darya; Khusnutdinova, Elza.
  • Dzhaubermezov M; Federal State Educational Institution of Higher Education, Ufa University of Science and Technology, 450076 Ufa, Russia.
  • Ekomasova N; Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences, 450054 Ufa, Russia.
  • Mustafin R; Federal State Educational Institution of Higher Education, Ufa University of Science and Technology, 450076 Ufa, Russia.
  • Gabidullina L; Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences, 450054 Ufa, Russia.
  • Galimova Y; Federal State Educational Institution of Higher Education, Bashkir State Medical University, 450008 Ufa, Russia.
  • Nurgalieva A; Federal State Educational Institution of Higher Education, Ufa University of Science and Technology, 450076 Ufa, Russia.
  • Valova Y; Federal State Educational Institution of Higher Education, Ufa University of Science and Technology, 450076 Ufa, Russia.
  • Prokofyeva D; Federal State Educational Institution of Higher Education, Ufa University of Science and Technology, 450076 Ufa, Russia.
  • Khusnutdinova E; Federal Institution of Science, Ufa Research Institute of Occupational Health and Human Ecology, 450106 Ufa, Russia.
Genes (Basel) ; 13(12)2022 12 13.
Article in English | MEDLINE | ID: covidwho-2163300
ABSTRACT
Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate cancer, colorectal cancer, breast cancer, and cervical cancer. Genotyping was performed on 540 supposedly healthy individuals of 5 Finno-Permic populations from the territories of the European part of the Russian Federation. There was a statistically significant difference between Veps and most of the studied populations in the rs4986774 locus of the CYP2D6 gene; data on the rs3892097 locus of the CYP2D6 gene shows that Izhemsky Komis are different from the Mordovian and Udmurt populations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytochrome P-450 CYP2D6 / Cytochrome P-450 Enzyme System Limits: Humans Country/Region as subject: Asia / Europa Language: English Year: 2022 Document Type: Article Affiliation country: Genes13122353

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytochrome P-450 CYP2D6 / Cytochrome P-450 Enzyme System Limits: Humans Country/Region as subject: Asia / Europa Language: English Year: 2022 Document Type: Article Affiliation country: Genes13122353