Dyslipidemia and Inflammation as Hallmarks of Oxidative Stress in COVID-19: A Follow-Up Study.
Int J Mol Sci
; 23(23)2022 Dec 05.
Article
in English
| MEDLINE | ID: covidwho-2163436
ABSTRACT
Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution of COVID-19. This is an observational prospective study. The primary endpoint was to analyze the association between lipid peroxidation, lipid, and inflammatory profiles in COVID-19 patients. A multivariate regression analysis was employed. The secondary endpoint included the long-term follow-up of lipid profiles. COVID-19 patients presented significantly lower values in their lipid profile (total, low, and high-density lipoprotein cholesterol) with greater oxidative stress and inflammatory response compared to the healthy controls. Lipid peroxidation was the unique oxidative parameter with a significant association with the total cholesterol (OR 0.982; 95% CI 0.969-0.996; p = 0.012), IL1-RA (OR 0.999; 95% CI 0.998-0.999; p = 0.021) IL-6 (OR 1.062; 95% CI 1.017-1.110; p = 0.007), IL-7 (OR 0.653; 95% CI 0.433-0.986; p = 0.042) and IL-17 (OR 1.098; 95% CI 1.010-1.193; p = 0.028). Lipid abnormalities recovered after the initial insult during long-term follow-up (IQR 514 days); however, those with high LPO levels at hospital admission had, during long-term follow-up, an atherogenic lipid profile. Our study suggests that oxidative stress in COVID-19 is associated with derangements of the lipid profile and inflammation. Survivors experienced a recovery in their lipid profiles during long-term follow-up, but those with stronger oxidative responses had an atherogenic lipid profile.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Atherosclerosis
/
Dyslipidemias
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Ijms232315350
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