Statins Use in Patients with Cardiovascular Diseases and COVID-19 Outcomes: An Italian Population-Based Cohort Study.
J Clin Med
; 11(24)2022 Dec 17.
Article
in English
| MEDLINE | ID: covidwho-2163477
ABSTRACT
BACKGROUND:
The role of statins among patients with established cardiovascular diseases (CVDs) who are hospitalized with COVID-19 is still debated. This study aimed at assessing whether the prior use of statins was associated with a less severe COVID-19 prognosis.METHODS:
Subjects with CVDs infected with SARS-CoV-2 and hospitalized between 20 February 2020 and 31 December 2020 were selected. These were classified into two mutually exclusive groups statins-users and non-users of lipid-lowering therapies (non-LLT users). The relationship between statins exposure and the risk of Mechanical Ventilation (MV), Intensive Care Unit (ICU) access and death were evaluated by using logistic and Cox regressions models.RESULTS:
Of 1127 selected patients, 571 were statins-users whereas 556 were non-LLT users. The previous use of statins was not associated with a variation in the risk of need of MV (Odds Ratio [OR] 1.00; 95% Confidence Intervals [CI] 0.38-2.67), ICU access (OR 0.54; 95% CI 0.22-1.32) and mortality at 14 days (Hazard Ratio [HR] 0.42; 95% CI 0.16-1.10). However, a decreased risk of mortality at 30 days (HR 0.39; 95% CI 0.18-0.85) was observed in statins-users compared with non-LLT users.CONCLUSIONS:
These findings support the clinical advice for patients CVDs to continue their treatment with statins during SARS-CoV-2 infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Jcm11247492
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