A Novel Coronavirus and a Broad Range of Viruses in Kenyan Cave Bats.
Viruses
; 14(12)2022 12 17.
Article
in English
| MEDLINE | ID: covidwho-2163629
ABSTRACT
BACKGROUND AND METHODS:
To investigate virus diversity in hot zones of probable pathogen spillover, 54 oral-fecal swabs were processed from five bat species collected from three cave systems in Kenya, using metagenome sequencing.RESULTS:
Viruses belonging to the Astroviridae, Circoviridae, Coronaviridae, Dicistroviridae, Herpesviridae and Retroviridae were detected, with unclassified viruses. Retroviral sequences were prevalent; 74.1% of all samples were positive, with distinct correlations between virus, site and host bat species. Detected retroviruses comprised Myotis myotis, Myotis ricketti, Myotis daubentonii and Galidia endogenous retroviruses, murine leukemia virus-related virus and Rhinolophus ferrumequinum retrovirus (RFRV). A near-complete genome of a local RFRV strain with identical genome organization and 2.8% nucleotide divergence from the prototype isolate was characterized. Bat coronavirus sequences were detected with a prevalence of 24.1%, where analyses on the ORF1ab region revealed a novel alphacoronavirus lineage. Astrovirus sequences were detected in 25.9%of all samples, with considerable diversity. In 9.2% of the samples, other viruses including Actinidia yellowing virus 2, bat betaherpesvirus, Bole tick virus 4, Cyclovirus and Rhopalosiphum padi virus were identified.CONCLUSIONS:
Further monitoring of bats across Kenya is essential to facilitate early recognition of possibly emergent zoonotic viruses.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA Viruses
/
Chiroptera
/
Astroviridae
/
Alphacoronavirus
/
COVID-19
/
Herpesviridae
Type of study:
Observational study
/
Randomized controlled trials
Limits:
Animals
Country/Region as subject:
Africa
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
V14122820
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