Investigation of the Relationship between the Use of Statins with the Mortality Rate and Duration of Hospitalization Due to Covid-19

ABSTRACT

Introduction: Statins are a group of lipid-lowering medications that have anti-inflammatory and immune system-modulating effects. Considering the existence of severe inflammatory reactions in patients with covid-19, this study aimed to investigate the effects of statins on the mortality rate of covid-19 patients. Material(s) and Method(s) The present research is a descriptive-analytical case-control study that was carried out in the first half of 2021 at Kowsar Hospital in Semnan, Iran. The study was conducted on 191 patients taking statins as the case group and 191 patients with no history of taking statins. Demographic and clinical information of the patients who met the inclusion criteria of the research were extracted from the files and collected in the researcher's questionnaire. Finally, the results were statistically analyzed using SPSS software version 26. Result(s) In this study, a case group of 191 people, who had a history of taking statins, and a control group of 191 people, who did not use statins, were investigated. The average age of people was 64.7 years. Among the studied patients, 51.7% were men and 48.3% were women. Most of the patients were hospitalized for 4 days. Also, 351 patients were discharged and 32 people died. After analyzing the data, no significant relationship was observed between the use of statin and mortality due to Covid-19. Discussion and Conclusion(s) According to the results of this study, no relationship was observed between the use of statins and the reduction of mortality caused by covid-19. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.