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Assessment of Changes in the Microbiological Parameters of the Oral Fluid in Patients Who Underwent Sovid-19 with Complete Edentulism before and after Prosthetics
NeuroQuantology ; 20(15):6734-6739, 2022.
Article in English | EMBASE | ID: covidwho-2164832
ABSTRACT
Organs such as the mouth, nose and eyes are the gateway for the coronavirus. If favorable conditions for the increase of infection are created in the oral mucosa with a decrease in immunity, the virus binds to the ACE-2 molecule (angiotensin-converting enzyme 2 membrane protein) and affects the epithelium. In the future, if the oral cavity is not protected, not only the mucous membrane of the oral cavity, but also the tissues around the teeth and the throat, as well as petechiae and stomach ulcers, can be observed [1, 2, 6, 7]. The process of development of ulcers in the oral cavity painful inflammation of the papillae of the tongue (day), then the appearance of an erythematous spot (day), which turns into irregular and asymptomatic ulcers;therefore, many patients may be unaware of an oral ulcer due to the absence of pain (Chaux-Bodard et al., 2020). The burning sensation in the mouth (22.4%) could be due to several causes (eg, candida infection, dry mouth, mouth ulceration, or medications). A viral infection can weaken the immune system, causing secondary infections such as oral thrush. Candidiasis is the most common opportunistic infection in HIV (Nokta, 2008) and has also been reported in Covid-19 (dos Santos et al., 2020). The manifestation of oral lesions in patients with Covid-19 may be related to the direct or indirect effect of SARSCoV-2 on the oral mucosa, hypersensitivity to drugs taken during Covid-19 infection, the patient's susceptibility to the disease itself, or the duration of hospitalization. The SARS-CoV-2 virus infects human cells through angiotensin converting enzyme (ACE-2) receptors, since ACE-2 acts as the primary host cell receptor for this virus [4, 5, 8]. The oral cavity is an open biological system, in which there is a constant balance between pathogenic factors, such as viruses, bacteria, and the body's defenses. However, such an important balance is often attacked, both due to the multiplication and accelerated development of microorganisms and viruses, and due to the weakening of the very factors of general and especially local immune defense [3]. Immunoglobulins and lytic enzymes play an important role in the body's defense system;they are a component of immunity that-provides protection against pathogens (a wide range of bacteria, fungi, viruses), and also participate in the development of inflammation processes, maintenance and regulation of the adaptive immune system. One of the important components of the complex mechanism of innate immunity are neutrophils, when activated by pathogenic or opportunistic microorganisms, a wide range of anti-inflammatory cytokines is secreted. Copyright © 2022, Anka Publishers. All rights reserved.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: English Journal: NeuroQuantology Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Experimental Studies Language: English Journal: NeuroQuantology Year: 2022 Document Type: Article