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Multipolymer microsphere delivery of SARS-CoV-2 antigens.
Shahjin, Farah; Patel, Milankumar; Machhi, Jatin; Cohen, Jacob D; Nayan, Mohammad Ullah; Yeapuri, Pravin; Zhang, Chen; Waight, Emiko; Hasan, Mahmudul; Abdelmoaty, Mai Mohamed; Dash, Prasanta K; Zhou, You; Andreu, Irene; Gendelman, Howard E; Kevadiya, Bhavesh D.
  • Shahjin F; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Patel M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Machhi J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Cohen JD; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Nayan MU; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Yeapuri P; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Zhang C; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Waight E; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Hasan M; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
  • Abdelmoaty MM; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Dash PK; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
  • Zhou Y; Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, USA.
  • Andreu I; RI Consortium of Nanoscience and Nanotechnology and Department of Chemical Engineering University of Rhode Island, RI, USA.
  • Gendelman HE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA. Electronic address: hegendel@unmc.edu.
  • Kevadiya BD; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5800, USA.
Acta Biomater ; 158: 493-509, 2023 03 01.
Article in English | MEDLINE | ID: covidwho-2245092
ABSTRACT
Effective antigen delivery facilitates antiviral vaccine success defined by effective immune protective responses against viral exposures. To improve severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigen delivery, a controlled biodegradable, stable, biocompatible, and nontoxic polymeric microsphere system was developed for chemically inactivated viral proteins. SARS-CoV-2 proteins encapsulated in polymeric microspheres induced robust antiviral immunity. The viral antigen-loaded microsphere system can preclude the need for repeat administrations, highlighting its potential as an effective vaccine. STATEMENT OF

SIGNIFICANCE:

Successful SARS-CoV-2 vaccines were developed and quickly approved by the US Food and Drug Administration (FDA). However, each of the vaccines requires boosting as new variants arise. We posit that injectable biodegradable polymers represent a means for the sustained release of emerging viral antigens. The approach offers a means to reduce immunization frequency by predicting viral genomic variability. This strategy could lead to longer-lasting antiviral protective immunity. The current proof-of-concept multipolymer study for SARS-CoV-2 achieve these metrics.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Acta Biomater Year: 2023 Document Type: Article Affiliation country: J.actbio.2022.12.043

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Acta Biomater Year: 2023 Document Type: Article Affiliation country: J.actbio.2022.12.043