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Effectiveness of COVID-19 vaccines on hospitalization and death in Guilan, Iran: a test-negative case-control study.
Heidarzadeh, Abtin; Amini Moridani, Mohammadreza; Khoshmanesh, Saman; Kazemi, Samira; Hajiaghabozorgi, Marziyeh; Karami, Manoochehr.
  • Heidarzadeh A; Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: abtinh@gmail.com.
  • Amini Moridani M; Deputy of Health, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: Mohammad.amini@gums.ac.ir.
  • Khoshmanesh S; Deputy of Health, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: khoshmaneshsaman@gmail.com.
  • Kazemi S; Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address: kazemisamira75@gmail.com.
  • Hajiaghabozorgi M; Deputy of Health, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: Bozorgi_arezoo@yahoo.com.
  • Karami M; School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: Man.karami@yahoo.com.
Int J Infect Dis ; 128: 212-222, 2023 Mar.
Article in English | MEDLINE | ID: covidwho-2262601
ABSTRACT

OBJECTIVES:

The present study was conducted to estimate the effectiveness of (BBIBP)-CorV (Sinopharm), ChAdOx1-S/nCoV-19 (AZD1222, Oxford-AstraZeneca), rAd26-rAd5 (Gam-COVID-Vac, Sputnik V), and BIV1-CovIran (COVIran Barekat) and BBV152 COVAXIN (Bharat Biotech) vaccines against hospitalization and death of COVID-19 in Guilan Province of Iran from May 22 to December 21, 2021.

METHODS:

This test-negative case-control study was conducted on the population aged 5 years and above by extracting information from local databases (The Medical Care Monitoring Center and The Integrated Health System). A logistic regression analysis was performed to estimate the effectiveness of the vaccines against COVID-19 hospitalization and death.

RESULTS:

The total study population was 42,084, including 19,500 cases (with a positive Reverse Transcriptase-Polymerase Chain Reaction test admitted to hospitals in Guilan Province) and 22,586 controls (with a negative Reverse Transcriptase-Polymerase Chain Reaction test). Among the admitted patients, 1887 deaths occurred. The maximum effectiveness of BBIBP-CorV (Sinopharm) in preventing temporary hospitalization and regular hospitalization was observed 151 days after receiving the second dose, 95% (95% CI 67-99.4%) and 85% (95% CI 77-91%) respectively. The maximum effectiveness of the BBIBP-CorV (Sinopharm) vaccine 91-120 days after receiving the second dose against death was showed 56% (95% CI 33-71%). The maximum effectiveness of ChAdOx1-S/nCoV-19 (AZD1222, Oxford-AstraZeneca) and BIV1-CovIran (COVIran Barekat) in preventing regular hospitalization and death was observed 121-150 and 61-90 days (respectively) after receiving the second dose, reaching 98% (95% CI 94-99%) and 92% (95% CI 48-99%), respectively for ChAdOx1-S/nCoV-19 and 95% (95% CI 91-97%) and 89% (95% CI 55-98%) respectively, for BIV1-CovIran.

CONCLUSION:

For almost all vaccines, the study observed an increase in effectiveness against hospitalization and death over time.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 / Hospitalization Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 / Hospitalization Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2023 Document Type: Article