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An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells.
Nicolas, Alexandre; Sannier, Gérémy; Dubé, Mathieu; Nayrac, Manon; Tauzin, Alexandra; Painter, Mark M; Goel, Rishi R; Laporte, Mélanie; Gendron-Lepage, Gabrielle; Medjahed, Halima; Williams, Justine C; Brassard, Nathalie; Niessl, Julia; Gokool, Laurie; Morrisseau, Chantal; Arlotto, Pascale; Tremblay, Cécile; Martel-Laferrière, Valérie; Finzi, Andrés; Greenplate, Allison R; Wherry, E John; Kaufmann, Daniel E.
  • Nicolas A; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Sannier G; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Dubé M; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Nayrac M; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Tauzin A; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Painter MM; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Goel RR; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Laporte M; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Gendron-Lepage G; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Medjahed H; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Williams JC; Immune Health®, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Brassard N; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Niessl J; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Gokool L; Immune Health®, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Morrisseau C; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Arlotto P; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Tremblay C; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Martel-Laferrière V; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Finzi A; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Greenplate AR; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
  • Wherry EJ; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.
  • Kaufmann DE; Centre de Recherche du CHUM, Montréal, QC H2X 0A9 Canada.
iScience ; 26(1): 105904, 2023 Jan 20.
Article in English | MEDLINE | ID: covidwho-2210554
ABSTRACT
Spacing the first two doses of SARS-CoV-2 mRNA vaccines beyond 3-4 weeks raised initial concerns about vaccine efficacy. While studies have since shown that long-interval regimens induce robust antibody responses, their impact on B and T cell immunity is poorly known. Here, we compare SARS-CoV-2 naive donors B and T cell responses to two mRNA vaccine doses administered 3-4 versus 16 weeks apart. After boost, the longer interval results in a higher magnitude and a more mature phenotype of RBD-specific B cells. While the two geographically distinct cohorts present quantitative and qualitative differences in T cell responses at baseline and after priming, the second dose led to convergent features with overall similar magnitude, phenotype, and function of CD4+ and CD8+ T cell responses at post-boost memory time points. Therefore, compared to standard regimens, a 16-week interval has a favorable impact on the B cell compartment but minimally affectscell immunity.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research Topics: Vaccines Language: English Journal: IScience Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research Topics: Vaccines Language: English Journal: IScience Year: 2023 Document Type: Article