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Development and Validation of an Acute Respiratory Distress Syndrome Prediction Model in Coronavirus Disease 2019: Updated Lung Injury Prediction Score.
Tekin, Aysun; Qamar, Shahraz; Sharma, Mayank; Singh, Romil; Malinchoc, Michael; Bansal, Vikas; Deo, Neha; Bogojevic, Marija; Valencia-Morales, Diana J; Zec, Simon; Zorko-Garbajs, Nika; Sharma, Nikhil; Lal, Amos; Sanghavi, Devang K; Cartin-Ceba, Rodrigo; Khan, Syed A; La Nou, Abigail T; Cherian, Anusha; Zabolotskikh, Igor B; Kumar, Vishakha K; Kashyap, Rahul; Walkey, Allan J; Domecq, Juan P; Yadav, Hemang; Gajic, Ognjen; Odeyemi, Yewande E.
  • Tekin A; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Qamar S; Post-baccalaureate Research Education Program, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN, USA.
  • Sharma M; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Singh R; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Malinchoc M; Malinchoc Research Consulting, LLC, Rochester, MN, USA.
  • Bansal V; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Deo N; Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA.
  • Bogojevic M; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Valencia-Morales DJ; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Zec S; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Zorko-Garbajs N; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Department of Vascular Neurology and Intensive Therapy, University Medical Centre Ljubljana, Slovenia.
  • Sharma N; Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Lal A; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Sanghavi DK; Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL, USA.
  • Cartin-Ceba R; Division of Pulmonary, Department of Medicine and Department of Critical Care Medicine, Mayo Clinic, Scottsdale, AZ, USA.
  • Khan SA; Division of Critical Care Medicine, Mayo Clinic Health System, Mankato, MN, USA.
  • La Nou AT; Division of Critical Care Medicine, Mayo Clinic Health System, Eau Claire, WI, USA.
  • Cherian A; Department of Anesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
  • Zabolotskikh IB; Department of Anesthesiology, Intensive Care Medicine and Transfusiology, Kuban State Medical University with affiliation Territorial Hospital #2, Krasnodar, Russia.
  • Kumar VK; Society of Critical Care Medicine, Mount Prospect, IL, USA.
  • Kashyap R; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
  • Walkey AJ; Pulmonary Center, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Evans Center of Implementation and Improvement Sciences, Boston University School of Medicine, Boston, MA, USA.
  • Domecq JP; Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Yadav H; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Gajic O; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Odeyemi YE; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA. Electronic address: Odeyemi.Yewande@mayo.edu.
Mayo Clin Proc ; 98(5): 736-747, 2023 05.
Article in English | MEDLINE | ID: covidwho-2319813
ABSTRACT

OBJECTIVE:

To develop and validate an updated lung injury prediction score for coronavirus disease 2019 (COVID-19) (c-LIPS) tailored for predicting acute respiratory distress syndrome (ARDS) in COVID-19. PATIENTS AND

METHODS:

This was a registry-based cohort study using the Viral Infection and Respiratory Illness Universal Study. Hospitalized adult patients between January 2020 and January 2022 were screened. Patients who qualified for ARDS within the first day of admission were excluded. Development cohort consisted of patients enrolled from participating Mayo Clinic sites. The validation analyses were performed on remaining patients enrolled from more than 120 hospitals in 15 countries. The original lung injury prediction score (LIPS) was calculated and enhanced using reported COVID-19-specific laboratory risk factors, constituting c-LIPS. The main outcome was ARDS development and secondary outcomes included hospital mortality, invasive mechanical ventilation, and progression in WHO ordinal scale.

RESULTS:

The derivation cohort consisted of 3710 patients, of whom 1041 (28.1%) developed ARDS. The c-LIPS discriminated COVID-19 patients who developed ARDS with an area under the curve (AUC) of 0.79 compared with original LIPS (AUC, 0.74; P<.001) with good calibration accuracy (Hosmer-Lemeshow P=.50). Despite different characteristics of the two cohorts, the c-LIPS's performance was comparable in the validation cohort of 5426 patients (15.9% ARDS), with an AUC of 0.74; and its discriminatory performance was significantly higher than the LIPS (AUC, 0.68; P<.001). The c-LIPS's performance in predicting the requirement for invasive mechanical ventilation in derivation and validation cohorts had an AUC of 0.74 and 0.72, respectively.

CONCLUSION:

In this large patient sample c-LIPS was successfully tailored to predict ARDS in COVID-19 patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Lung Injury / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Humans Language: English Journal: Mayo Clin Proc Year: 2023 Document Type: Article Affiliation country: J.mayocp.2022.11.021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Lung Injury / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Humans Language: English Journal: Mayo Clin Proc Year: 2023 Document Type: Article Affiliation country: J.mayocp.2022.11.021