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Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees.
Yu, Pei; Liu, Zijian; Zhu, Zhuoqi; Yang, Jiaqing; Deng, Min; Chen, Mingxiao; Lai, Changchun; Kong, Weiya; Xiong, Shilong; Wan, Li; Mai, Weikang; Chen, Lu; Lei, Yu; Khan, Shahzad Akbar; Ruan, Jianfeng; Kang, An; Guo, Xuguang; Zhou, Qiang; Li, Wenrui; Chen, Zheng; Liang, Yuemei; Li, Pingchao; Zhang, Lei; Ji, Tianxing.
  • Yu P; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Liu Z; State Key Laboratories of Respiratory Diseases, Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510535, China.
  • Zhu Z; Clinical Laboratory Medicine Department, Dongguan Ninth People's Hospital, Dongguan, 523016, China.
  • Yang J; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
  • Deng M; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Chen M; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Lai C; Clinical Laboratory Medicine Department, Maoming People's Hospital, Maoming, 525000, China.
  • Kong W; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Xiong S; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Wan L; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Mai W; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Chen L; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Lei Y; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Khan SA; Laboratory of Pathology, Department of Pathobiology, University of Poonch Rawalakot Azad Kashmir Pakistan 12350, Pakistan.
  • Ruan J; Hospital Infection-Control Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Kang A; Medical Examination Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Guo X; Department of Clinical Laboratory Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510140, China.
  • Zhou Q; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Li W; Clinical Laboratory Medicine Department, Dongguan Ninth People's Hospital, Dongguan, 523016, China.
  • Chen Z; Kidney Transplant Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. Electronic address: docchenzheng@163.com.
  • Liang Y; Clinical Laboratory Medicine Department, Dongguan Ninth People's Hospital, Dongguan, 523016, China. Electronic address: 784604898@qq.com.
  • Li P; State Key Laboratories of Respiratory Diseases, Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510535, China. Electronic address: li_pingchao@gibh.ac.cn.
  • Zhang L; Kidney Transplant Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China; Department of Organ Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, 510630, China. Electronic address: 517728181@qq.com.
  • Ji T; Clinical Laboratory Medicine Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China; Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guan
Virol Sin ; 38(2): 233-243, 2023 Apr.
Article in English | MEDLINE | ID: covidwho-2165946
ABSTRACT
Homologous booster, heterologous booster, and Omicron variants breakthrough infection (OBI) could improve the humoral immunity against Omicron variants. Questions concerning about memory B cells (MBCs) and T cells immunity against Omicron variants, features of long-term immunity, after booster and OBI, needs to be explored. Here, comparative analysis demonstrate antibody and T cell immunity against ancestral strain, Delta and Omicron variants in Omicron breakthrough infected patients (OBIPs) are comparable to that in Ad5-nCoV boosted healthy volunteers (HVs), higher than that in inactivated vaccine (InV) boosted HVs. However, memory B cells (MBCs) immunity against Omicron variants was highest in OBIPs, followed by Ad5-nCoV boosted and InV boosted HVs. OBIPs and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs, and lower naïve MBCs and atypical MBCs relative to both vaccine boosted HVs. Collectively, these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Breakthrough Infections Topics: Vaccines / Variants Limits: Humans Language: English Journal: Virol Sin Journal subject: Virology Year: 2023 Document Type: Article Affiliation country: J.virs.2022.12.008

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Breakthrough Infections Topics: Vaccines / Variants Limits: Humans Language: English Journal: Virol Sin Journal subject: Virology Year: 2023 Document Type: Article Affiliation country: J.virs.2022.12.008